A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation
A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation
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DOI：
10.1039/c6gc02888h
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发表时间：
2017-03-21
期刊：
影响因子：
9.8
通讯作者：
George, Michael W.
中科院分区：
文献类型：
--
作者：
DeLaney, Erica N.;Lee, Darren S.;George, Michael W.
本文介绍了一种用于连续紫外光化学的新型环形反应器，它使用了易于互换的不同波长的准分子灯。该反应器具有窄间隙以形成用于有效照射分子的材料薄膜。通过研究离散波长灯（222、282和308 nm）对N-邻苯二甲酰亚氨基丁酸钾1的反应的影响来证明其用途。通过将反应器与Amberlyst清除剂和固体酸催化剂NbOPO 4组合以获得在单个套叠工艺中获得的第二产物3来说明反应器集成到多步工艺中的能力。3中的三环支架是在几种生物活性化合物中发现的基序，并且有可能作为新药物产品的合成子。
This paper describes a new annular reactor for continuous UV photochemistry, which uses easily interchangeable excimer lamps of different wavelengths. The reactor has narrow clearance to form thin films of material for efficient irradiation of molecules. Its use is demonstrated by investigating the effect of discrete wavelength lamps (222, 282 and 308 nm) on the reaction of potassium N-phthalimidobutanoate 1. The ability of the reactor to be integrated into multistep processes is illustrated by combining it with an Amberlyst scavenger and a solid acid catalyst, NbOPO4, to access a second product 3 that is obtained in a single telescoped process. The tricyclic scaffold in 3 is a motif found in several biologically active compounds and has possibilities as a synthon for new pharmaceutical products.