Binaural unmasking of frequency-following responses in rat amygdala.
Binaural unmasking of frequency-following responses in rat amygdala.
复制标题
大鼠杏仁核频率跟随反应的双耳揭示。
DOI：
10.1152/jn.91055.2008
复制
发表时间：
2009-03
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
在自然环境中生存的小动物，如大鼠，往往取决于精确的神经编码的生命威胁的声学信号，双耳揭露物种特异性的疼痛呼叫是特别重要的。本研究探讨了物种特异性的尾痛喋喋不休是如何在大鼠杏仁核，它接收传入从听觉丘脑和听觉联合皮层，以及是否杏仁核代表的喋喋不休可以双耳揭露。结果表明，基频（F0）为2.1kHz的高频振动能在麻醉大鼠杏仁外侧核诱发显著的锁相频率跟随反应（FFRs）。双耳呈现的震颤的F0的FFR对耳间时间差（ITD）敏感，具有同侧耳领先的偏好，以及显示双耳抑制的特征。当增加耳间相关掩蔽噪声且同侧震颤导致对侧震颤时，在震颤和掩蔽噪声之间引入ITD差异显著增强（未掩蔽）FFR。通过化学方法阻断听觉联合皮层中的兴奋性谷氨酸受体，进一步增强了双耳暴露。当用F0为0.7 kHz的谐波音调复合体代替颤振时，双耳抑制特征和双耳暴露仅保留2.1 kHz的谐波，而不是音调F0。这些结果表明，频率依赖性的上升双耳调制和皮质下降调制的精确的听觉编码的震颤在杏仁核是至关重要的处理危及生命的声学信号在嘈杂的，甚至混响的环境。
Survival in natural environments for small animals such as rats often depends on precise neural coding of life-threatening acoustic signals, and binaural unmasking of species-specific pain calls is especially critical. This study investigated how species-specific tail-pain chatter is represented in the rat amygdala, which receives afferents from both auditory thalamus and auditory association cortex, and whether the amygdaloid representation of the chatter can be binaurally unmasked. The results show that chatter with a fundamental frequency (F0) of 2.1 kHz was able to elicit salient phase-locked frequency-following responses (FFRs) in the lateral amygdala nucleus in anesthetized rats. FFRs to the F0 of binaurally presented chatter were sensitive to the interaural time difference (ITD), with the preference of ipsilateral-ear leading, as well as showing features of binaural inhibition. When interaurally correlated masking noises were added and ipsilateral chatter led contralateral chatter, introducing an ITD disparity between the chatter and masker significantly enhanced (unmasked) the FFRs. This binaural unmasking was further enhanced by chemically blocking excitatory glutamate receptors in the auditory association cortex. When the chatter was replaced by a harmonic tone complex with an F0 of 0.7 kHz, both the binaural-inhibition feature and the binaural unmasking were preserved only for the harmonic of 2.1 kHz but not the tone F0. These results suggest that both frequency-dependent ascending binaural modulations and cortical descending modulations of the precise auditory coding of the chatter in the amygdala are critical for processing life-threatening acoustic signals in noisy and even reverberant environments.
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影响因子：
1.2
作者：
James R. Wilson;A. Krishnan
通讯作者：
James R. Wilson;A. Krishnan
影响因子：
2.5
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通讯作者：
M. N. Wallace;L. Anderson;A. Palmer
影响因子：
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作者：
D. Zhang;Liang Li;J. Kelly;S. Wu
通讯作者：
D. Zhang;Liang Li;J. Kelly;S. Wu
影响因子：
2
作者：
Malmierca, MS;Hernández, O;Rees, A
通讯作者：
Rees, A
影响因子：
2.5
作者：
LEDOUX, JE;RUGGIERO, DA;REIS, DJ
通讯作者：
REIS, DJ