DIFFUSE PROLONGED DEPRESSION OF CEREBRAL OXIDATIVE-METABOLISM FOLLOWING CONCUSSIVE BRAIN INJURY IN THE RAT - A CYTOCHROME-OXIDASE HISTOCHEMISTRY STUDY
DIFFUSE PROLONGED DEPRESSION OF CEREBRAL OXIDATIVE-METABOLISM FOLLOWING CONCUSSIVE BRAIN INJURY IN THE RAT - A CYTOCHROME-OXIDASE HISTOCHEMISTRY STUDY
复制标题
DOI：
10.1016/0006-8993(91)91429-5
复制
发表时间：
1991-12-13
期刊：
影响因子：
2.9
通讯作者：
BECKER, DP
中科院分区：
文献类型：
--
作者：
HOVDA, DA;YOSHINO, A;BECKER, DP
采用大鼠侧方液压冲击伤作为脑震荡模型，用组织化学方法检测了损伤后不同时间不同结构中细胞色素氧化酶活性的变化。脑震荡后，损伤部位同侧大脑皮质中染色质氧化酶(CO)活性呈弥漫性下降，最快开始于伤后1天，并持续至伤后10天。同侧背侧海马区也表现出损伤后CO活性的降低，但不像大脑皮层那样严重。这些结果表明，在脑震荡后的几天里，氧化代谢主要在大脑皮层和海马区受到抑制。我们认为，代谢抑制的这段时间可能描绘了一段时间，在这段时间内，受损的大脑无法正常运作，因此容易受到第二次侮辱。
Utilizing a lateral fluid percussion injury as a model of cerebral concussion, rats were studied histochemically measuring the degree of cytochrome oxidase activity present within different structures at different times following injury. After concussion, the cerebral cortex ipsilateral to the site of injury exhibited a diffuse decrease in its level of chromotome oxidase (CO) activity beginning at as soon as one day and lasting for up to 10 days after the insult. The ipsilateral dorsal hippocampus also exhibited an injury-induced decrease in CO activity, however, it was not as severe as in the cortex. These results indicate that oxidative metabolism is depressed primarily within the cerebral cortex and hippocampus for several days following a cerebral concussion. We propose that this period of metabolic depression may delineate a period of time during which the injured brain is unable to function normally and thus would be vulnerable to a second insult.