Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells
Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells
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DOI：
10.1128/aac.00708-11
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发表时间：
2011-11-01
影响因子：
4.9
通讯作者：
Kweon, Dae-Hyuk
中科院分区：
文献类型：
--
作者：
Kim, Jun-Seob;Heo, Paul;Kweon, Dae-Hyuk
我们表明，3-[4-（4-甲氧基苯基）哌嗪-1-基]哌啶-4-基联苯-4-羧酸酯（C10），筛选出的化学库，选择性地杀死耐受抗生素治疗的细菌持久性，但不影响正常的抗生素敏感细胞。C10通过使持留菌回复为对抗生素敏感的细胞而导致持留菌对抗生素诱导的细胞死亡。这项工作是第一次证明细菌持久性的根除是基于单一的化学补充。这种化学品在阐明持久性机制方面应该是多功能的。
We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence.