Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice
Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice
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金属蛋白酶1组织抑制剂对裸鼠体内转染人胃癌细胞转移的抑制作用
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
Motoharu Seiki
中科院分区：
文献类型：
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作者：
Michio Watanabe;Yutaka Takahashi;Takahito Ohta;Masayashi Mai;Takuma Sasaki;Motoharu Seiki
金属蛋白酶组织抑制因子(TIMPs)是降解细胞外基质的基质金属蛋白酶(MMPs)的负调节因子。采用裸鼠原位移植模型，评价高转移人胃腺癌细胞系KKLS和外源TIMP-1基因转移性细胞的转移能力。
Tissue inhibitors of metalloproteinases (TIMPs) act as negative regulators of matrix metalloproteinases (MMPs) that degrade extracellular matrix. We evaluated the metastatic ability of the highly metastatic human gastric cell line KKLS, and that of cells transfected with exogenous TIMP‐1 gene by the orthotopic transplantation model in nude mice.
影响因子：
11.2
作者：
Y. DeClerck;N. Perez;Hiroyuki Shimada;T. Boone;K. Langley;Shirley M. Taylor
通讯作者：
Y. DeClerck;N. Perez;Hiroyuki Shimada;T. Boone;K. Langley;Shirley M. Taylor
影响因子：
10.3
作者：
ALVAREZ, OA;CARMICHAEL, DF;DECLERCK, YA
通讯作者：
DECLERCK, YA