Association of single nucleotide polymorphisms in TCF2 with type 2 diabetes susceptibility in a Han Chinese population.
Association of single nucleotide polymorphisms in TCF2 with type 2 diabetes susceptibility in a Han Chinese population.
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TCF2单核苷酸多态性与中国汉族人群2型糖尿病易感性的关系
DOI：
10.1371/journal.pone.0052938
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Fu S
中科院分区：
文献类型：
--
作者：
Zhang X;Qiao H;Zhao Y;Wang X;Sun H;Liu A;Xu L;Sun D;Jin Y;Yu Y;Meng X;Bai J;Chen F;Fu S
Hepatocyte nuclear factor 1β (HNF1β), a transcription factor encoded by the transcription factor 2 gene (TCF2), plays a critical role in pancreatic cell formation and glucose homeostasis. It has been suggested that single nucleotide polymorphisms (SNPs) of TCF2 are associated with susceptibility to type 2 diabetes (T2D). However, published results are inconsistent and inclusive. To further investigate the role of these common variants, we examined the association of TCF2 polymorphisms with the risk of T2D in a Han population in northeastern China. We genotyped five SNPs in 624 T2D patients and 630 healthy controls by using a SNaPshot method, and evaluated the T2D risk conferred by individual SNPs and haplotypes. In the single-locus analysis, we found that rs752010, rs4430796 and rs7501939 showed allelic differences between T2D patients and healthy controls, with an OR of 1.26 (95% CI 1.08–1.51, P = 0.003), an OR of 1.23 (95% CI 1.06–1.55, P = 0.001) and an OR of 1.28 (95% CI 1.10–1.61, P = 0.001), respectively. Genotype association analysis of each locus also revealed that the homozygous carriers of the at-risk allele had a significant increased T2D risk compared to homozygous carriers of the other allele (OR 1.78, 95% CI 1.20–2.64 for rs752010; OR 1.82, 95% CI 1.24–2.67 for rs4430796; OR 1.95, 95% CI 1.31–2.90 for rs7501939), even after Bonferroni correction for multiple comparisons. Besides, the haplotype-based analysis demonstrated that AGT in block rs752010-rs4430796-rs7501939 was associated with about 30% increase in T2D risk (OR 1.31, 95% CI 1.09–1.57, P = 0.01). Our findings suggested that TCF2 variants may be involved in T2D risk in a Han population of northeastern China. Larger studies with ethnically diverse populations are warranted to confirm the results reported in this investigation.
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影响因子：
7.7
作者：
Wang C;Hu C;Zhang R;Bao Y;Ma X;Lu J;Qin W;Shao X;Lu J;Xu J;Lu H;Xiang K;Jia W
通讯作者：
Jia W
DOI：
10.1073/pnas.0405776102
发表时间：
2005-02-01
影响因子：
11.1
作者：
Haumaitre, C;Barbacci, E;Cereghini, S
通讯作者：
Cereghini, S
影响因子：
2.1
作者：
Mensink, Marco
通讯作者：
Mensink, Marco
影响因子：
4
作者：
Wheeler, Eleanor;Barroso, Ines
通讯作者：
Barroso, Ines
影响因子：
19.6
作者：
Dudziak, Karin;Mottalebi, Nima;Ryffel, Gerhart U.
通讯作者：
Ryffel, Gerhart U.