Antidepressant-like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus
Antidepressant-like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus
复制标题
四羟基芪葡萄糖苷对小鼠的抗抑郁样作用：海马 BDNF 信号级联的参与
DOI：
10.1111/cns.12708
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发表时间：
2017
影响因子：
5.5
通讯作者：
Jiang Bo
中科院分区：
文献类型：
--
作者：
Wang Hao;Zhao Ying;Wang Ying-Jie;Song Lu;Wang Jin-Liang;Huang Chao;Zhang Wei;Jiang Bo
Background and AimsCurrent antidepressants in clinic need weeks of administration and always have significant limitations. Tetrahydroxystilbene glucoside (TSG) is one of the major bioactive ingredients ofPolygonum multiflorumwith neuroprotective effects. This study aimed to evaluate the antidepressant effects of TSG in mice.MethodsThe antidepressant‐like effects of TSG in mice were examined in the forced swim test (FST), tail suspension test (TST), and chronic social defeat stress (CSDS) model of depression. The effects of CSDS and TSG on the hippocampal brain‐derived neurotrophic factor (BDNF) signaling pathway and neurogenesis were further investigated. Moreover, the pharmacological inhibitors and lentiviral‐shRNA were used to explore the antidepressant mechanisms of TSG.ResultsTSG produced antidepressant‐like effects in the FST and TST and also reversed the CSDS‐induced depressive‐like symptoms. Moreover, TSG treatment significantly restored the decreased hippocampal BDNF signaling pathway and neurogenesis in CSDS mice. Importantly, blockade of the hippocampal BDNF system fully abolished the antidepressant‐like effects of TSG in mice.ConclusionIn conclusion, TSG produces antidepressant‐like effects in mice via enhancement of the hippocampal BDNF system.
