Neuronal Oscillations and Functional Interactions Between Resting State Networks: Effects of Alcohol Intoxication
Neuronal Oscillations and Functional Interactions Between Resting State Networks: Effects of Alcohol Intoxication
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静息状态网络之间的神经元振荡和功能相互作用：酒精中毒的影响
DOI：
10.1002/hbm.22418
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发表时间：
2014-07-01
影响因子：
4.8
通讯作者：
Mantini, Dante
中科院分区：
文献类型：
--
作者：
Lei, Xu;Wang, Yulin;Mantini, Dante
功能磁共振成像(FMRI)研究表明，健康大脑中的静息状态活动被组织成多个覆盖遥远区域的大规模网络。静息状态fMRI研究的一个关键发现是背侧注意网络(DAN)和默认模式网络(DMN)之间存在典型的反相关性，在任务执行过程中，这两个网络分别被激活和去激活。以往的研究表明，酒精可以调节脑网络的激活/去激活平衡，并引起脑电(EEG)测量的振荡活动的显著变化。然而，我们对酒精引起的带限脑电功率的变化及其与DAN和DMN之间功能相互作用的潜在联系的了解仍然非常有限。在这里，我们解决这个问题，通过使用同步的EEG-fMRI检查静息状态下酒精给药对神经元的影响。我们的发现显示，与安慰剂相比，饮酒后脑电在theta频段(4-8赫兹)的脑电功率增加，这一点在额叶皮质表现突出。更有趣的是，该频段额叶紧张性脑电活动的增加与DAN和DMN额叶成分之间的反相关性更强。此外，在报告在饮酒后感到欣快感的受试者中，EEG theta功率和DAN-DMN反相关性相对更大，这可能是由于前额叶皮质施加的抑制减弱所致。总体而言，我们的发现表明，缓慢的大脑节律是大脑网络之间动态功能交互的原因。它们也证实了EEG-fMRI在中枢神经系统药物研究中的适用性和潜在的有用性。Hum Brain Mapp 35：3517-3528,2014。(C)2013年威利期刊公司。
Functional magnetic imaging (fMRI) studies showed that resting state activity in the healthy brain is organized into multiple large-scale networks encompassing distant regions. A key finding of resting state fMRI studies is the anti-correlation typically observed between the dorsal attention network (DAN) and the default mode network (DMN), whichduring task performanceare activated and deactivated, respectively. Previous studies have suggested that alcohol administration modulates the balance of activation/deactivation in brain networks, as well as it induces significant changes in oscillatory activity measured by electroencephalography (EEG). However, our knowledge of alcohol-induced changes in band-limited EEG power and their potential link with the functional interactions between DAN and DMN is still very limited. Here we address this issue, examining the neuronal effects of alcohol administration during resting state by using simultaneous EEG-fMRI. Our findings show increased EEG power in the theta frequency band (4-8 Hz) after administration of alcohol compared to placebo, which was prominent over the frontal cortex. More interestingly, increased frontal tonic EEG activity in this band was associated with greater anti-correlation between the DAN and the frontal component of the DMN. Furthermore, EEG theta power and DAN-DMN anti-correlation were relatively greater in subjects who reported a feeling of euphoria after alcohol administration, which may result from a diminished inhibition exerted by the prefrontal cortex. Overall, our findings suggest that slow brain rhythms are responsible for dynamic functional interactions between brain networks. They also confirm the applicability and potential usefulness of EEG-fMRI for central nervous system drug research. Hum Brain Mapp 35:3517-3528, 2014. (c) 2013 Wiley Periodicals, Inc.