In vitro effect of asbestos fibers on polymorphonuclear leukocyte function.
In vitro effect of asbestos fibers on polymorphonuclear leukocyte function.
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石棉纤维对多形核白细胞功能的体外影响。
DOI：
10.1159/000233061
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Salvaggio,JE
中科院分区：
文献类型：
--
作者：
Doll,NJ;Stankus,RP;Goldbach,S;Salvaggio,JE
温石棉和闪石石棉纤维与正常人外周血多形核白细胞（PMN）孵育导致PMN代谢活性的显着刺激和有毒氧副产物的产生，如通过化学发光（CL）测量。虽然所有的石棉纤维测试的细胞毒性PMN，细胞毒性和CL变化不成比例的纤维类型。直闪石石棉产生的PMN细胞毒性最大。它还抑制PMN吞噬乳胶珠的最，并诱导最大的PMN CL反应的纤维类型检查。我们推测，石棉引起的释放有毒的氧副产品从中性粒细胞浸润到肺泡可能有助于石棉肺的发病机制。
Incubation of chrysotile and amphibole asbestos fibers with normal human peripheral blood polymorphonuclear leukocytes (PMN) resulted in a significant stimulation of PMN metabolic activity and generation of toxic oxygen by-products as measured by chemiluminescence (CL). Although all asbestos fibers tested were cytotoxic to PMN, cytotoxicity and CL varied disproportionately with fiber type. Anthophyllite asbestos produced the greatest PMN cytotoxicity. It also depressed PMN phagocytosis of latex beads the most and induced the greatest PMN CL response of the fiber types examined. We postulate that asbestos-induced release of toxic oxygen by-products from PMN which have infiltrated into the pulmonary alveoli may contribute to disease pathogenesis in asbestosis.