Bisphenol A in relation to behavior and learning of school-age children
Bisphenol A in relation to behavior and learning of school-age children
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DOI：
10.1111/jcpp.12050
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发表时间：
2013-08-01
影响因子：
7.6
通讯作者：
Cho, Soo-Churl
中科院分区：
文献类型：
--
作者：
Hong, Soon-Beom;Hong, Yun-Chul;Cho, Soo-Churl
背景：双酚A(BPA)对啮齿动物和非人灵长类动物的大脑和行为有影响，但很少有研究关注其与人类神经行为的关系。本研究旨在探讨双酚A环境暴露与儿童神经行为的关系。方法：对1,089名8-11岁儿童的尿双酚A浓度以及行为和学习特征进行评估。主要的测量工具是儿童行为检查表(CBCL)和学习障碍评估量表(LDES)。结果：尿BPA水平与CBCL总分呈正相关，与学习智商呈负相关。经多次比较校正后，CBCL焦虑/抑郁得分与CBCL焦虑/抑郁得分呈显著线性相关，与LDES听力得分呈二次相关。结论：环境暴露于双酚A可能与儿童的行为和学习发展有关。结果表明，它们之间可能存在单调关系。
Background: Bisphenol A (BPA) has been shown to affect brain and behavior in rodents and nonhuman primates, but there are few studies focusing on its relationship to human neurobehavior. We aimed to investigate the relationship between environmental exposure to BPA and childhood neurobehavior. Methods: Urinary BPA concentrations and behavioral and learning characteristics were assessed in a general population of 1,089 children, aged 8-11 years. The mainoutcomemeasures were the Child Behavior Checklist (CBCL) andthe Learning Disability Evaluation Scale (LDES). Results: Urinary levels of BPA were positively associated with the CBCL total problems score and negatively associated with the learning quotient from the LDES. The linear association with the CBCL anxiety/depression score and the quadratic association with the LDES listening score were significant after correction for multiple comparisons. Conclusions: Environmental exposure to BPA might be associated with childhood behavioral and learning development. Theresults suggestpossiblenonmonotonicrelationships.