Human biomonitoring assessment values: Approaches and data requirements
Human biomonitoring assessment values: Approaches and data requirements
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DOI：
10.1016/j.ijheh.2011.06.002
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发表时间：
2011-09-01
影响因子：
6
通讯作者：
Wilhelm, Michael
中科院分区：
文献类型：
--
作者：
Angerer, Juergen;Aylward, Lesa L.;Wilhelm, Michael
人体生物监测 (HBM) 数据是评估人类在商业中接触化学品的非常有用的指标。为了评估与血液、尿液或其他生物基质中存在的化学物质相关的潜在健康风险，需要 HBM 评估值。虽然基于人体暴露反应数据的 HBM 评估值仍然是最具价值和可解释的评估值，但对于极少数化学品而言，存在足够的数据来表示此类值。因此，人们努力推导出 HBM 评估值，其中基于外部剂量的指导值（例如每日耐受摄入量）已转化为等效的生物监测水平。德国 HBM 委员会制定的 HBM 值和 Summit Toxicology 制定的生物监测等效值产生了概念上相似的评估值。这里提供的对这些值的发展的回顾展示了可用于扩大可得出此类评估值的化学品范围的示例和方法。迄今为止，我们已经发布了 80 多种化学品的 HBM 评估值，现在提供了可用于评估跨化学品和人群的 HBM 数据的工具。 (C) 2011 爱思唯尔有限公司。版权所有。
Human biomonitoring (HBM) data is a very useful metric for assessing human's exposures to chemicals in commerce. To assess the potential health risks associated with the presence of chemicals in blood, urine or other biological matrix requires HBM assessment values. While HBM assessment values based on human exposure-response data remain the most highly valuable and interpretable assessment values, enough data exists for such values for very few chemicals. As a consequence, efforts have been undertaken to derive HBM assessment values in which external dose based guidance values such as tolerable daily intakes have been translated into equivalent biomonitoring levels. The development of HBM values by the German HBM Commission and Biomonitoring Equivalents by Summit Toxicology has resulted in conceptually similar assessment values. The review of the development of these values provided here demonstrates examples and approaches that can be used to broaden the range of chemicals for which such assessment values can be derived. Efforts to date have resulted in the publication of HBM assessment values for more than 80 chemicals, and now provide tools that can be used for the evaluation of HBM data across chemicals and populations. (C) 2011 Elsevier GmbH. All rights reserved.