Mycobacterial antigens may be important in sarcoidosis pathogenesis
Mycobacterial antigens may be important in sarcoidosis pathogenesis
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DOI：
10.1097/01.mcp.0000239554.01068.94
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发表时间：
2006-09-01
影响因子：
3.3
通讯作者：
Newman, Lee S.
中科院分区：
文献类型：
--
作者：
Drake, Wonder Puryear;Newman, Lee S.
回顾的目的描述了最新的流行病学，分子和免疫学文献有关的感染性抗原在结节病发病机制的作用，重点在分枝杆菌和Proprionibacterium species.Recent发现最近的研究成功的分子分析和体液免疫的结节病患者的分枝杆菌抗原结节病的潜在作用，分枝杆菌在结节病的兴趣。一项研究提供了来自美国的结节病受试者中分枝杆菌的分子和免疫学证据。这些研究虽然是初步的，但为更深入地研究分枝杆菌在结节病发病机制中的潜在作用提供了基础。Proprionibacteria也被认为是结节病的一个原因;然而，一项在结节病和对照受试者的整个肺中检测到Proprionibacterium物种核酸的研究表明，这些生物体不太可能是致病的。概述虽然迄今为止的研究不满足Koch的假设，但它们确实进一步支持了以下假设：感染性抗原，特别是来自分枝杆菌的抗原，可能在某些结节病病例中起因果作用。在未来的研究中，旨在显示微生物抗原与结节病的相关性，调查导致风险的遗传风险因素将是重要的，以解释为什么有些患者被发现与微生物抗原有关，而其他人则没有。
Purpose of review To describe the most recent epidemiologic, molecular and immunologic literature related to the role of infectious antigens in sarcoidosis pathogenesis, with a focus upon Mycobacterium and Proprionibacterium species.Recent findings Recent studies of successful molecular analysis for and humoral immunity to mycobacterial antigens from sarcoidosis patients have renewed interest in a potential role of mycobacteria in sarcoidosis. One study provided molecular and immunologic evidence for mycobacteria among sarcoidosis subjects from the United States. These studies, while preliminary, provide the groundwork for more in-depth studies of the potential role of mycobacteria in sarcoidosis pathogenesis. Proprionibacteria have also been proposed as a cause of sarcoidosis; a study of the detection of Proprionibacterium species nucleic acids throughout the lung of sarcoidosis and control subjects, however, suggests that these organisms are less likely to be causal.Summary While the studies to date do not fulfill Koch's postulates, they do add further support to the hypothesis that infectious antigens, particularly those from mycobacteria, may have a causal role in some sarcoidosis cases. In future studies that purport to show an association of microbial antigen(s) with sarcoidosis, investigation of genetic risk factors contributing to risk will be important, in order to explain why some patients are found to have an association with microbial antigens and others are not.