Gene expression of angiotensinogen in adipose tissue of obese patients
Gene expression of angiotensinogen in adipose tissue of obese patients
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DOI：
10.1038/sj.ijo.0801305
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发表时间：
2000-06-01
影响因子：
4.9
通讯作者：
Mantero, F
中科院分区：
文献类型：
--
作者：
Giacchetti, G;Faloia, E;Mantero, F
近年来，在脂肪组织中发现了血管紧张素原（AGT）、血管紧张素转换酶（ACE）和血管紧张素Ⅱ受体（ATII）等组成RAS的基因。在动物模型中，脂肪组织中的血管紧张素原与肥胖相关的代谢改变和高血压的发病机制有关。本研究的目的是评估AGT基因在肥胖患者和瘦型受试者的内脏和皮下脂肪组织中的表达。AGT mRNA水平测定逆转录聚合酶链反应（RT-PCR）使用特异性引物。AGT mRNA在肥胖患者中以不同水平表达。内脏脂肪组织中的脂肪含量显著高于皮下脂肪组织。内脏脂肪组织AGT表达与BMI呈正相关，提示血管紧张素原可能是脂肪分布的决定因素，可能参与了向心性肥胖的多代谢综合征。
Recently, the genes of components of the renin-angiotensin system (RAS), namely angiotensinogen (AGT), angiotensin converting enzyme and angiotensin II receptor have been described in adipose tissue. In animal models the angiotensinogen in adipose tissue has been implicated in the pathogenesis of metabolic alterations and hypertension associated with obesity. The aim of our study was to evaluate the AGT gene expression both in visceral and subcutaneous adipose tissue in obese patients and lean subjects. AGT mRNA levels were measured by reverse transcriptase polymerase chain reaction (RT-PCR) using specific primers. AGT mRNA was expressed at variable levels in obese patients. It was significantly greater in visceral than in subcutaneous adipose tissue. Positive and significant correlation was found between the expression of AGT in visceral adipose tissue and BMI, These data suggest that angiotensinogen may be determinant of fat distribution and may be involved in the plurimetabolic syndrome of central obesity.