Determinants of attrition in a natural history study of Alzheimer disease
Determinants of attrition in a natural history study of Alzheimer disease
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DOI：
10.1097/00002093-199910000-00006
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发表时间：
1999-10-01
影响因子：
2.1
通讯作者：
Fillenbaum, GG
中科院分区：
文献类型：
--
作者：
Koss, E;Peterson, B;Fillenbaum, GG
本研究的目的是确定自然史研究中的一个三级护理样本阿尔茨海默病（AD）患者和对照组的磨损的决定因素。对1987年1月至1992年1月在阿尔茨海默病登记协会的25个地点招募的978例AD患者和466例年龄在50岁及以上的对照受试者进行了纵向研究;每年对受试者进行长达78个月的随访。描述性统计和多分类逻辑回归分析，以确定磨损的决定因素。在入组的1，444例受试者中，10.5%在初始评价后脱落，31.0%提供了至少两波数据，58.4%提供了完整随访。研究中心参与不足、非白人状态和患者配偶未入组研究可预测脱落;因死亡（可能排除脱落）而停止参与可预测继续参与研究。年龄、教育水平、痴呆的严重程度和疾病进展的速度不能预测辍学。研究中心级别承诺是继续参与AD自然史研究的最重要决定因素，其次是白色人种，以及包括丈夫和妻子，其中一人是患者，另一人是对照受试者。
The aim of the present study was to identify determinants of attrition in a natural history study of a tertiary care sample of patients with Alzheimer disease (AD) and control subjects. A longitudinal study was performed with 978 patients with AD and 466 control subjects age 50 years and older enrolled at 25 sites of the Consortium to Establish a Registry for Alzheimer's Disease between January 1987 and January 1992; subjects were followed annually for up to 78 months. Both descriptive statistics and polytomous logistic regressions were run to identify determinants of attrition. Of the 1,444 subjects enrolled, 10.5% dropped out after initial evaluation, 31.0% provided at least two waves of data, and 58.4% provided complete follow-up. Inadequate involvement by the site, non-white status, and patient's spouse not enrolled in the study were predictive of dropout; cessation of participation because of death (which may have precluded dropout) predicted continuation in the study. Age, level of education, severity of dementia, and rapidity of progression of disease did not predict dropout. Level-of-site commitment was the most significant determinant of continued participation in this natural history study of AD, followed by white race, and the inclusion of both husband and wife where one is a patient and the other a control subject.