Modulation of the brain's functional network architecture in the transition from wake to sleep.
Modulation of the brain's functional network architecture in the transition from wake to sleep.
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DOI：
10.1016/b978-0-444-53839-0.00018-1
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发表时间：
2011
影响因子：
--
通讯作者：
Petersen, Steven E.
中科院分区：
文献类型：
--
作者：
Larson-Prior, Linda J.;Power, Jonathan D.;Vincent, Justin L.;Nolan, Tracy S.;Coalson, Rebecca S.;Zempel, John;Snyder, Abraham Z.;Schlaggar, Bradley L.;Raichle, Marcus E.;Petersen, Steven E.
从安静的清醒休息到睡眠的过渡代表了对外部环境的注意力逐渐消失的时期。神经影像学方法已经提供了很多关于睡眠中神经活动模式转变的信息，但是对于从清醒到睡眠的过渡期中人脑网络的动态重构仍然知之甚少。对这些早期过渡状态的电生理测量和功能网络连接的分析表明，网络结构发生了微妙的变化，这与外部注意力减少和内部和自我参照处理增加是一致的。此外，下降到睡眠伴随着默认模式网络的前部和后部的连接性的丧失以及更局部组织的全局网络架构。这些数据澄清了清醒和睡眠之间的过渡期的复杂性和动态性，并建议需要更多的研究调查这些过程的动态。
The transition from quiet wakeful rest to sleep represents a period over which attention to the external environment fades. Neuroimaging methodologies have provided much information on the shift in neural activity patterns in sleep, but the dynamic restructuring of human brain networks in the transitional period from wake to sleep remains poorly understood. Analysis of electrophysiological measures and functional network connectivity of these early transitional states shows subtle shifts in network architecture that are consistent with reduced external attentiveness and increased internal and self-referential processing. Further, descent to sleep is accompanied by the loss of connectivity in anterior and posterior portions of the default-mode network and more locally organized global network architecture. These data clarify the complex and dynamic nature of the transitional period between wake and sleep and suggest the need for more studies investigating the dynamics of these processes.