Elevated serum copper levels in women with a history of post-partum depression
Elevated serum copper levels in women with a history of post-partum depression
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DOI：
10.1016/j.jtemb.2006.10.001
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发表时间：
2007-01-01
影响因子：
3.5
通讯作者：
Walsh, William J.
中科院分区：
文献类型：
--
作者：
Crayton, John W.;Walsh, William J.
先前的观察表明，血清铜（Cu）水平升高与产后抑郁症（PPD）之间可能存在关联。在这项研究中，我们检查了有产后抑郁症病史的已完成妊娠的女性的 Zri 和铜水平，并将她们与没有抑郁症的女性以及自称患有抑郁症但没有产后抑郁症病史的女性进行了比较。与非抑郁女性和无 PPD 病史的抑郁女性相比，有 PPD 病史的女性的铜水平显着更高。 78 名有 PPD 病史的女性的平均血清铜水平为 131 +/- 39 pg/dL，而 148 名无 PPD 病史的女性的平均血清铜水平为 111 +/- 25 pg/dL，非抑郁对照的平均血清铜水平为 106 +/- 20 μg/dL（p < 0.001）。三组中的 Zri 水平没有差异。由于铜水平存在显着差异，PPD 病史阳性组的铜/锌比率显着较高。铜和锌的水平在抑郁和非抑郁男性中没有显着差异，在非抑郁女性和非抑郁男性中也没有显着差异。与男性相比，抑郁女性的铜含量更高，但锌含量却没有。 Cu 值升高与 PPD 之间的关联性质目前尚不清楚。然而，铜在多种生理系统中发挥作用，可能与产后抑郁症的发生有关。 (c) 2006 年爱思唯尔有限公司。版权所有。
Previous observations suggested that there may be an association between elevated serum copper (Cu) levels and post-partum depression (PPD). In this study, we examined Zri and Cu levels in women with completed pregnancies who had a history of PPD and compared them to women who did not have depression, and to women who reported having been depressed, but without a history of PPD. Cu levels were significantly higher in women having a history of PPD compared both to non-depressed women and to depressed women without a history of PPD. The mean serum Cu level of 78 women with a history of PPD was 131 +/- 39 pg/dL compared with 111 +/- 25 pg/dL in 148 women without such a history, and 106 +/- 20 mu g/dL in non-depressed controls (p < 0.001). Zri levels did not differ across the three groups. Cu/Zn ratios were significantly higher in the PPD-history-positive group, due to the significant differences in Cu levels. Cu and Zn levels were not significantly different in depressed and non-depressed men, nor between non-depressed women and non-depressed men. Depressed women had higher Cu, but not Zn, levels compared with men. The nature of the association between elevated Cu values and PPD is, as yet, unknown; however Cu has roles in a variety of physiological systems that may be implicated in the development of PPD. (c) 2006 Elsevier GmbH. All rights reserved.