Synchronization analysis between heart rate variability and EEG activity before, during, and after epileptic seizure
Synchronization analysis between heart rate variability and EEG activity before, during, and after epileptic seizure
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DOI：
10.1515/bmt-2013-0139
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发表时间：
2014-08
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通讯作者：
D. Piper;K. Schiecke;L. Leistritz;Britta Pester;F. Benninger;M. Feucht;M. Ungureanu;R. Strungaru;H. Witte
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文献类型：
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作者：
D. Piper;K. Schiecke;L. Leistritz;Britta Pester;F. Benninger;M. Feucht;M. Ungureanu;R. Strungaru;H. Witte
摘要本文提出了一种新颖的心率（HR）成分与脑电（EEG）包络中节律同步分析的概念，它将时变分析应用于心率变异性（HRV）和脑电（EEG），并在儿童颞叶癫痫（TLE）中进行了测试。在去除与眼睛和运动相关的伪影之后，通过提供频带包络的频率选择性希尔伯特变换来计算EEG频带活动。通过Morlet小波相干性量化HRV和EEG包络之间的同步。采用替代数据方法检验时变相干性的统计学显著性。使用该处理方案，可以显示在发作的发作前期和早期发作后期中发生的HRV低频子带（0.08-0.12 Hz）和EEG δ包络（1.5-4 Hz）之间的显著相干值。以20秒的间隔对所有电极进行研究，并以时变模式对选定的电极对（T3 <$C3，T4 <$C4）进行研究。右半球TLE患者组的同步性比左半球组更明显。这种组特异性同步增强证实了右半球交感神经心脏控制低频HRV分量的偏侧化的假设。
Abstract An innovative concept for synchronization analysis between heart rate (HR) components and rhythms in EEG envelopes is represented; it applies time-variant analyses to heart rate variability (HRV) and EEG, and it was tested in children with temporal lobe epilepsy (TLE). After a removal of ocular and movement-related artifacts, EEG band activity was computed by means of the frequency-selective Hilbert transform providing envelopes of frequency bands. Synchronization between HRV and EEG envelopes was quantified by Morlet wavelet coherence. A surrogate data approach was adapted to test for statistical significance of time-variant coherences. Using this processing scheme, significant coherence values between a HRV low-frequency sub-band (0.08–0.12 Hz) and the EEG δ envelope (1.5–4 Hz) occurring both in the preictal and early postictal periods of a seizure can be shown. Investigations were performed for all electrodes at 20-s intervals and for selected electrode pairs (T3÷C3, T4÷C4) in a time-variant mode. Synchronization was more pronounced in the group of right hemispheric TLE patients than in the left hemispheric group. Such a group-specific augmentation of synchronization confirms the hypothesis of a right hemispheric lateralization of sympathetic cardiac control of the low-frequency HRV components.