Prognostic determinants in patients with stage IIIC and IV uterine papillary serous carcinoma
Prognostic determinants in patients with stage IIIC and IV uterine papillary serous carcinoma
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DOI：
10.1016/j.ygyno.2010.07.010
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发表时间：
2010-11-01
影响因子：
4.7
通讯作者：
del Carmen, Marcela G.
中科院分区：
文献类型：
--
作者：
Rauh-Hain, J. Alejandro;Growdon, Whitfield B.;del Carmen, Marcela G.
Objective. The aim of this study was to evaluate the survival impact of cytoreductive surgery and other prognostic determinants in patients with stage IIIC and IV uterine papillary serous carcinoma (UPSC).Methods. All patients with FIGO stage IIIC and IV UPSC who underwent surgical staging at the two participating institutions, between January 1, 1995 and December 31, 2007, were identified from the tumor registry database. The Kaplan-Meier method was used to generate overall survival (OS) data. Factors predictive of outcome were compared using the log-rank test and Cox regression analysis.Results. Analysis of 79 patients with stage IIIC-IV disease was performed. Optimal cytoreduction was associated with a median survival of 36 months, compared with 12 months for patients who underwent a suboptimal surgical effort (p = 0.001), and a disease-free survival (DFS) of 21 months vs. 10 months (p = 0.001), respectively. Regression analysis identified stage (HR = 2.4, p = 0.03), absence of visible residual disease (HR = 0.5, p = 0.03), and chemotherapy (HR = 0.1, p
