Repetitive transcranial magnetic stimulation has a beneficial effect on bradykinesia in Parkinson's disease.
Repetitive transcranial magnetic stimulation has a beneficial effect on bradykinesia in Parkinson's disease.
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重复经颅磁刺激对帕金森病的运动迟缓具有有益作用。
DOI：
10.1097/00001756-199902250-00027
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发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
Bastian Conrad
中科院分区：
文献类型：
--
作者：
H. Siebner;C. Mentschel;C. Auer;Bastian Conrad
对12例未经药物治疗的帕金森病（PD）患者进行了局灶性5 Hz重复经颅磁刺激（rTMS）对运动迟缓的影响。在2个单独的日子里，一个真正的rTMS应用于M1对侧更严重的影响肢体或额叶假rTMS应用3厘米前Fz以随机顺序。刺激强度低于静息运动阈值10%。在rTMS之前和之后20分钟，患者用食指对侧刺激M1进行15次连续指向运动。与假rTMS相比，对侧M1的real-rTMS导致总运动时间显著减少，而不影响终点准确性。我们的数据提供的证据表明，5 Hz rTMS超过M1可以改善PD患者的运动迟缓超过磁刺激的时间。
The effect of focal 5 Hz repetitive transcranial magnetic stimulation (rTMS) of the motor hand area (M1) on bradykinesia was studied in 12 unmedicated patients with Parkinson's disease (PD). On 2 separate days, a real-rTMS was applied to M1 contralaterally to the more severely affected limb or a frontal sham-rTMS was applied 3 cm anteriorly to Fz in a random order. Stimulus intensity was 10% below resting motor threshold. Before and 20 min after rTMS, patients performed 15 consecutive pointing movements with the index finger contralaterally to the stimulated M1. Compared with sham-rTMS, real-rTMS over the contralateral M1 caused a significant decrease in total movement time without affecting end-point accuracy. Our data provide evidence that 5 Hz rTMS over M1 can improve bradykinesia in PD patients beyond the time of magnetic stimulation.