Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
复制标题
DOI：
10.1073/pnas.94.11.5929
复制
发表时间：
1997-05-27
影响因子：
11.1
通讯作者：
Thompson, RF
中科院分区：
文献类型：
--
作者：
Kim, JJ;Shih, JC;Thompson, RF
与正常野生型小鼠相比，缺乏单胺氧化酶 A（MAOA）（一种代谢去甲肾上腺素和血清素等单胺的酶）的小鼠，其额叶皮层、海马体和小脑的去甲肾上腺素和血清素水平升高。由于这些区域的单胺与多种行为密切相关，我们 检查了 MAOA 突变小鼠的学习和记忆（使用情绪和运动任务），MAOA 缺陷小鼠表现出显着增强的经典恐惧调节（冻结音调和情境刺激）和逐步降低的抑制性回避学习。相比之下，这些突变小鼠的眨眼条件反射是正常的。缺乏 MAOA 的雌性小鼠也表现出正常物种典型的母性行为（筑巢、哺乳和取回幼崽）。这些结果表明，由于编码 MAOA 的基因缺失，单胺的慢性升高会导致情绪行为的选择性改变。
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice, Since monoamines in these areas are critically involved in a variety of behaviors, we examined learning and memory (using emotional and motor tasks) in MAOA mutant mice, The MAOA-deficient mice exhibited significantly enhanced classical fear conditioning (freezing to both tone and contextual stimuli) and step-down inhibitory avoidance learning. In contrast, eyeblink conditioning was normal in these mutant mice, The female MAOA-deficient mice also displayed normal species-typical maternal behaviors (nesting, nursing, and pup retrieval), These results suggest that chronic elevations of monoamines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior.