Long non-coding RNA polymorphisms on 8q24 are associated with the prognosis of gastric cancer in a Chinese population
Long non-coding RNA polymorphisms on 8q24 are associated with the prognosis of gastric cancer in a Chinese population
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8q24长非编码RNA多态性与中国人群胃癌预后相关
DOI：
10.7717/peerj.8600
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发表时间：
2020-02-21
期刊：
影响因子：
2.7
通讯作者：
Jiang，Jing
中科院分区：
文献类型：
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作者：
Zhang，Yangyu;Wu，Yanhua;Jiang，Jing
研究背景胃癌(GC)仍是中国的第三大癌症死亡原因。尽管全基因组关联研究已经确定了8q24上的几个单核苷酸多态(SNPs)与胃癌风险之间的关联，但这些SNPs在中国人群中对GC预后的作用还没有得到充分的评估。因此，本研究旨在探讨8q24长非编码RNA(LncRNA)基因多态性与胃癌预后的关系。方法对726例手术切除的胃癌患者进行基因分型，探讨8q24位点转录的CCAT1(rs10087719，rs7816475)、PCAT1(Rs1026411)、PRNCR1(rs12682421，rs13252298)和CASC8(rs1562430，rs4871789，rs6983267)8个SNP与胃癌预后的关系。结果携带rs12682421 AA基因的患者较携带GG/GA基因的患者存活时间短(HR=1.39，95%可信区间(CI)1.09~1.78)。与CC/CT基因型相比，rs1562430的TT基因型与死亡风险增加相关(HR=1.38，95%CI[1.06~1.80])。此外，研究结果还证实rs1026411单核苷酸多态是胃癌患者生存不良的独立预后因素。携带AA/AG变异基因的患者与携带GG基因的患者相比，死亡风险增加36%(HR=1.36，95%CI[1.06-1.74])。提示rs12682421、rs1026411和rs1562430 SNPs可能与胃癌的生存有关，可作为胃癌的预后指标。
Background Gastric cancer (GC) remains the third leading cause of cancer death in China. Although genome-wide association studies have identified the association between several single nucleotide polymorphisms (SNPs) on 8q24 and the risk of GC, the role of these SNPs in the prognosis of GC in Chinese populations has not yet been fully evaluated. Therefore, this study was conducted to explore the association between long non-coding RNA (lncRNA) polymorphisms on 8q24 and the prognosis of GC. Methods We genotyped 726 surgically resected GC patients to explore the association between eight SNPs in the lncRNAs CCAT1 (rs10087719, rs7816475), PCAT1 (rs1026411), PRNCR1 (rs12682421, rs13252298), and CASC8 (rs1562430, rs4871789, rs6983267) transcribed from the 8q24 locus and the prognosis of GC in a Chinese population. Results We found that the patients carrying rs12682421 AA genotypes survived for a shorter time than those with the GG/GA genotype (HR = 1.39, 95% confidence interval (CI) [1.09–1.78]). Compared with the CC/CT genotype, the TT genotype of rs1562430 was associated with an increased risk of death (HR = 1.38, 95% CI [1.06–1.80]). Furthermore, the results also identified the rs1026411 SNP as an independent prognostic factor for poor survival in GC patients. Patients carrying AA/AG variant genotypes had a 36% increased risk of death compared to those carrying the GG genotype (HR = 1.36, 95% CI [1.06–1.74]). These findings suggested that the rs12682421, rs1026411 and rs1562430 SNPs may contribute to the survival of GC and be prognostic markers for GC.