Ipsilateral breast tumor control following hypofractionated and conventional fractionated whole-breast irradiation for early breast cancer: a long-term follow-up
Ipsilateral breast tumor control following hypofractionated and conventional fractionated whole-breast irradiation for early breast cancer: a long-term follow-up
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早期乳腺癌大分割和常规分割全乳腺照射后的同侧乳腺肿瘤控制：长期随访
DOI：
10.1007/s12282-020-01134-8
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发表时间：
2021
期刊：
影响因子：
4
通讯作者：
Karasawa K
中科院分区：
文献类型：
--
作者：
Yoshida-Ichikawa Y;Horomoto Y;Shikama N;Yanagisawa N;Koyamnagi A;Arakawa A;Saito M;Karasawa K
日本乳腺癌患者接受大分割全乳照射（HF-WBI）的长期随访尚未得到充分的记录。因此，我们比较了HF-WBI和传统的分割（CF）-WBI.MethodsPatients与0-II期乳腺癌接受部分乳房切除术的治疗结果符合这项前瞻性观察研究。HF-WBI包括43.2戈伊，分16次照射至整个乳房，对于手术切缘阳性或小于5 mm的患者，额外的瘤床增强为8.1戈伊，分3次。共调查了2006年至2008年间接受治疗的615例患者（400例：HF-WBI和215例：CF-WBI）。根据年龄、肿瘤分级和边缘状态进行倾向评分匹配，并对372例匹配病例进行了调查，以检查与乳腺内肿瘤复发（IBTR）相关的因素。结果随访时间中位数为9.4年，年龄和边缘状态是与IBTR发生相关的独立因素（P = 0.006和0.016，分别）。HF-WBI和CF-WBI后10年同侧乳腺肿瘤控制（IBTC）率分别为96.5%和95.3%（P = 0.606）。根据切缘状态的10年IBTC率分别为88.0%，切缘阳性，94.9%，5mm切缘阴性（P = 0.014.ConclusionsThere是没有差异的IBTC之间CF-WBI和HF-WBI在我们的患者。手术切缘阳性是与CF-WBI和HF-WBI后IBTC率独立相关的风险因素。需要进一步的研究来为手术切缘阳性的患者建立适当的治疗策略。
PurposeLong-term follow-up of Japanese women with breast cancer who underwent hypofractionated whole-breast irradiation (HF-WBI) has not been well documented. Therefore, we compared the treatment results of HF-WBI and conventional fractionated (CF)-WBI.MethodsPatients with stage 0–II breast cancer receiving partial mastectomy were eligible for this prospective observational study. The HF-WBI consisted of 43.2 Gy in 16 fractions to the whole breast, with an additional tumor-bed boost of 8.1 Gy in three fractions for patients with positive or less than 5 mm surgical margins. A total of 615 patients (400: HF-WBI and 215: CF-WBI) who were treated between 2006 and 2008 were investigated. Propensity score matching was conducted based on age, tumor grade, and margin status, and 372 matched cases were investigated for examining factors relating to intrabreast tumor recurrence (IBTR).ResultsWith a median follow-up period of 9.4 years, age and margin status were independent factors associated with IBTR occurrence (P= 0.006 and 0.016, respectively). The 10-year ipsilateral breast tumor control (IBTC) rates after HF-WBI and CF-WBI were 96.5% and 95.3%, respectively (P= 0.606). The 10-year IBTC rates according to margin status were 88.0% with positive margins, 94.9% with 5 mm margins, and 98.0% with negative margins (P= 0.014).ConclusionsThere was no difference in IBTC between CF-WBI and HF-WBI in our patients. Positive surgical margin was a risk factor independently associated with IBTC rates after CF-WBI and HF-WBI. Further investigation is required to establish adequate treatment strategies for patients with positive surgical margins.
DOI：
10.1016/j.ijrobp.2013.11.012
发表时间：
2014-03-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Moran MS;Schnitt SJ;Giuliano AE;Harris JR;Khan SA;Horton J;Klimberg S;Chavez-MacGregor M;Freedman G;Houssami N;Johnson PL;Morrow M
通讯作者：
Morrow M
DOI：
--
发表时间：
2007
期刊：
Nihon rinsho. Japanese journal of clinical medicine
影响因子：
--
作者：
Y. Takatsuka
通讯作者：
Y. Takatsuka
DOI：
10.6004/jnccn.2017.0072
发表时间：
2017-05-01
影响因子：
13.4
作者：
Salerno, Kilian E.
通讯作者：
Salerno, Kilian E.