Hippocampus, amygdala and global brain changes 10 years after childhood traumatic brain injury
Hippocampus, amygdala and global brain changes 10 years after childhood traumatic brain injury
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DOI：
10.1016/j.ijdevneu.2010.12.003
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发表时间：
2011-04-01
影响因子：
1.8
通讯作者：
Anderson, V. A.
中科院分区：
文献类型：
--
作者：
Beauchamp, M. H.;Ditchfield, M.;Anderson, V. A.
儿童创伤性脑损伤（TBI）导致发育中的大脑受损，特别是在严重受伤的个体中。然而，人们对儿童TBI后大脑的长期结构方面知之甚少。本研究使用磁共振成像容积测量法调查了TBI后10年的大脑完整性，样本包括49名轻度、中度和重度TB患者，对照来自儿科数据库的20名具有可比年龄和性别分布的个体的规范性样本进行评价。在灰色和白色物质中研究了结构完整性，并通过手动分割两个感兴趣的区域（海马体，杏仁核），可能容易受到儿童TBI的影响。结果表明，更严重的损伤导致灰色和白色脑物质减少，而所有TBI严重程度导致脑脊液体积增加和海马体积减小。此外，与轻度和中度患者相比，在严重损伤患者中检测到杏仁核体积增大，这表明儿童TBI可能通过弥漫性病理变化破坏某些脑区域的发育。研究结果强调了儿童TBI对大脑的持久影响，以及在早期损伤后长期监测大脑结构的重要性。(C)2010 ISDN。由爱思唯尔有限公司出版。保留所有权利。
Traumatic brain injury (TBI) in children results in damage to the developing brain, particularly in severely injured individuals. Little is known, however, of the long-term structural aspects of the brain following childhood TBI. This study investigated the integrity of the brain 10 years post-TBI using magnetic resonance imaging volumetrics in a sample of 49 participants with mild, moderate and severe TB!, evaluated against a normative sample of 20 individuals from a pediatric database with comparable age and gender distribution. Structural integrity was investigated in gray and white matter, and by manually segmenting two regions of interest (hippocampus, amygdala), potentially vulnerable to the effects of childhood TBI. The results indicate that more severe injuries caused a reduction in gray and white brain matter, while all TBI severity levels resulted in increased volumes of cerebrospinal fluid and smaller hippocampal volumes. In addition, enlarged amygdala volumes were detected in severely injured patients compared to their mild and moderate counterparts, suggesting that childhood TBI may disrupt the development of certain brain regions through diffuse pathological changes. The findings highlight the lasting impact of childhood TBI on the brain and the importance of monitoring brain structure in the long-term after early injury. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.