Epidemiology and comorbidities of patients with chronic urticaria in Korea: A nationwide population-based study
Epidemiology and comorbidities of patients with chronic urticaria in Korea: A nationwide population-based study
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DOI：
10.1111/1346-8138.14075
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发表时间：
2018-01-01
影响因子：
3.1
通讯作者：
Youn, Sang Woong
中科院分区：
文献类型：
--
作者：
Kim, Bo Ri;Yang, Seungkeol;Youn, Sang Woong
很少有基于人群的研究关注慢性荨麻疹（CU）或慢性自发性荨麻疹（CSU）的流行病学和合并症。本研究的目的是获得韩国CU和CSU相关的流行病学和合并症的信息。我们使用国家健康保险数据库进行了横断面分析。基于国际疾病分类第10版的算法用于识别CU和CSU患者，并使用年龄-性别调整的logistic回归模型评估这些患者的合并症风险。2010 - 2013年4年间CU和CSU的年均患病率分别为3.08%和1.40%。CU和CSU的患病率女性高于男性（分别为1：1.39和1：1.34），高峰分别出现在0-9岁和70- 79岁。校正年龄和性别后，CU和CSU患者的CU/CSU相关疾病患病率显著高于无CU患者（平均校正比值比8.46，95%可信区间8.10-8.83）。过敏性鼻炎、药物过敏、哮喘、甲状腺疾病和癌症是最常见的合并症。胃癌、甲状腺癌、肝癌和前列腺癌是最常见的癌症。本研究提供了韩国CU和CSU患病率及其合并症的大量流行病学数据。与CU和CSU的患者施加了更高的负担，在特定的合并症，比那些没有CU。
Few population-based studies have focused on the epidemiology and comorbidities of chronic urticaria (CU) or chronic spontaneous urticaria (CSU). The objective of this study was to obtain information on the epidemiology and comorbidities associated with CU and CSU in Korea. We conducted a cross-sectional analysis using a national health insurance database. An algorithm based on the International Classification of Diseases, 10th revision, was used for the identification of patients with CU and CSU, and an age-sex adjusted logistic regression model was used to assess the risk of comorbidities in these patients. The average annual prevalence rates of CU and CSU during the 4-year period between 2010 and 2013 were 3.08% and 1.40%, respectively. The prevalence rates of CU and CSU were higher in women than men (1:1.39 and 1:1.34, respectively) and peaked at 0-9 and 70-79years, respectively. After adjustment for age and sex, the patients with CU and CSU were found to have a significantly higher prevalence rate of CU/CSU-related diseases, compared with those without CU (mean adjusted odds ratio, 8.46; 95% confidence interval, 8.10-8.83). Allergic rhinitis, drug allergies, asthma, thyroid diseases and cancers were the most common comorbidities. Stomach, thyroid, liver and prostate cancers were the most prevalent cancers. This study provides large epidemiological data on the prevalence rates of CU and CSU, and their comorbidities, in Korea. Patients with CU and CSU impose a higher burden, in terms of specific comorbidities, than those without CU.