Calcium channels: mechanisms of selectivity, permeation, and block.
Calcium channels: mechanisms of selectivity, permeation, and block.
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钙通道：选择性、渗透和阻断机制。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
R. Rosenberg
中科院分区：
文献类型：
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作者：
R. Tsien;P. Hess;E. McCleskey;R. Rosenberg
内容观点和概述265拒绝或亲和的选择性？266来自反转电位的渗透率序列...267不同的渗透率序列来自单一电导269大的有机阳离子渗透...269个钙结合部位的性质......。.。.......270钙离子结合位点的早期证据............270证据支持多离子孔271具有两个结合位点的单列孔.....273来自单一记录的新证据278钙离子的直接相互作用278钙离子通道278电压依赖的区块280孔的功能对称性280离子-离子相互作用282是构象变化涉及选择性？284可能的结构含义285多种类型的钙通道286心肌和骨骼肌中DHP敏感的通道286 T-型钙通道......287 N型钙通道287结束语。288
CONTENTS PERSPECTIVES AND OVERVIEW 265 SELECTIVITY BY REJECTION OR AFFINITY? 266 Permeability Sequence Derived from Reversal Potentials ... 267 Diff erent Permeability Sequence Derived from Unitary Conductances 269 Permeation by Large Organic Cations .... 269 PROPERTIES OF CALCIUM BINDING SITES ...... . ....... . ....... ........ 270 Early evidence for a Ca2+ Binding Site ......... ...... 270 Evidence Favoring a Multi-Ion Pore 271 A SINGLE-FILE PORE WITH TWO BINDING SITES ..... 273 NEW EVIDENCE FROM UNITARY RECORDINGS 278 Direct Interaction ofCa2+ and the Ca'+ ChanneL 278 Voltage-Dependent Block 280 Functional Symmetry of the Pore 280 Ion-Ion Interactions 282 ARE CONFORMATIONAL CHANGES INVOLVED IN SELECTIVITY? 284 POSSIBLE STRUCTURAL IMPLICATIONS 285 MULTIPLE TYPES OF CALCIUM CHANNELS 286 DHP-Sensitive Channels in Cardiac and Skeletal Muscle 286 T-Type Calcium Channels ....... ........ 287 N-Type Calcium Channels 287 CONCLUDING REMARKS . 288