Breath-Hold 1H-Magnetic Resonance Spectroscopy for Intrahepatic Lipid Quantification at 3 Tesla
Breath-Hold 1H-Magnetic Resonance Spectroscopy for Intrahepatic Lipid Quantification at 3 Tesla
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DOI：
10.1097/rct.0b013e3181cefb89
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发表时间：
2010-05-01
影响因子：
1.3
通讯作者：
Torriani, Martin
中科院分区：
文献类型：
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作者：
Bredella, Miriam A.;Ghomi, Reza Hosseini;Torriani, Martin
目的：比较屏气 1H-磁共振波谱 (1H-MRS) 与呼吸门控 1H-MRS 和计算机断层扫描 (CT) 对肝脏脂质含量的定量。方法：对 23 名绝经前妇女进行肝脏屏气点分辨单体素 1H-MRS，然后进行 3 特斯拉呼吸门控 1H-MRS 和通过肝脏的 CT 切片。对 6 名志愿者的 1H-MRS 扫描间变异性进行了评估。计算 Pearson 相关系数、Bland-Altman 95% 一致性限和一致性相关系数。 结果：屏气与呼吸门控 1H-MRS 之间存在很强的相关性（r = 0.94，P < 0.0001；一致性相关系数，0.75）。使用 Bland-Altman 分析，除 2 个数据点外，所有数据点均在一致范围内。两种 1H-MRS 技术均具有较低的扫描间变异性。两种 1H-MRS 技术与肝脏 CT 衰减值均呈负相关。结论：屏气 1H-MRS 是测量 3 特斯拉肝脏脂质含量的可靠方法。肝脏的屏气 1H-MRS 提供的数据与长时间呼吸门控技术获得的数据密切相关。
Objective: To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content.Methods: Twenty-three premenopausal women underwent breath-hold point-resolved single-voxel 1H-MRS of the liver followed by respiratory-gated 1H-MRS at 3 Tesla and CT slice through the liver. Interscan variability for 1H-MRS was assessed in 6 volunteers. Pearson correlation coefficients, Bland-Altman 95% limit of agreement, and concordance correlation coefficients were calculated.Results: There was a strong correlation between breath-hold and respiratory-gated 1H-MRS (r = 0.94, P < 0.0001; concordance correlation coefficient, 0.75). Using Bland-Altman analysis, all but 2 data points were within the limits of agreement. Both 1H-MRS techniques had low interscan variability. There was an inverse correlation of both 1H-MRS techniques with CT attenuation values of the liver.Conclusions: Breath-hold 1H-MRS is a reliable method to measure hepatic lipid content at 3 Tesla. Breath-hold 1H-MRS of the liver provides data that closely correlates with that obtained from longer-duration respiratory-gated technique.