O-GlcNAcylation and Metabolic Reprograming in Cancer.
O-GlcNAcylation and Metabolic Reprograming in Cancer.
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DOI：
10.3389/fendo.2014.00145
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发表时间：
2014
影响因子：
5.2
通讯作者：
Krześlak A
中科院分区：
文献类型：
--
作者：
Jóźwiak P;Forma E;Bryś M;Krześlak A
虽然癌症代谢在过去十年中受到了相当大的关注，但我们对其细节的了解仍然是零碎的。改变的细胞代谢是癌症最重要的标志之一。癌细胞表现出以有氧糖酵解为特征的异常葡萄糖代谢，这种现象称为瓦尔堡效应。加速的葡萄糖摄取和糖酵解是癌细胞的主要特征，使其能够密集生长和增殖。越来越多的证据表明，O-GlcNAc转移酶（OGT），一种负责用N-乙酰葡糖胺修饰蛋白质的酶，可能作为一种营养传感器，将己糖胺生物合成途径与致癌信号传导和参与葡萄糖和脂质代谢的因子的调节联系起来。最近的研究表明，癌症中的代谢重编程与表观遗传水平的变化有关。O-GlcNAc化似乎在表观基因组响应细胞代谢状态的调节中起重要作用。通过组蛋白修饰和基因转录复合物的组装，OGT可以影响对细胞代谢重要的基因的表达。本文综述了最近的研究结果，O-GlcNAc依赖的信号通路，转录因子，酶，和表观遗传变化参与代谢重编程的癌症。
Although cancer metabolism has received considerable attention over the past decade, our knowledge on its specifics is still fragmentary. Altered cellular metabolism is one of the most important hallmarks of cancer. Cancer cells exhibit aberrant glucose metabolism characterized by aerobic glycolysis, a phenomenon known as Warburg effect. Accelerated glucose uptake and glycolysis are main characteristics of cancer cells that allow them for intensive growth and proliferation. Accumulating evidence suggests that O-GlcNAc transferase (OGT), an enzyme responsible for modification of proteins with N-acetylglucosamine, may act as a nutrient sensor that links hexosamine biosynthesis pathway to oncogenic signaling and regulation of factors involved in glucose and lipid metabolism. Recent studies suggest that metabolic reprograming in cancer is connected to changes at the epigenetic level. O-GlcNAcylation seems to play an important role in the regulation of the epigenome in response to cellular metabolic status. Through histone modifications and assembly of gene transcription complexes, OGT can impact on expression of genes important for cellular metabolism. This paper reviews recent findings related to O-GlcNAc-dependent regulation of signaling pathways, transcription factors, enzymes, and epigenetic changes involved in metabolic reprograming of cancer.
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影响因子：
4.3
作者：
Dang, Chi V.
通讯作者：
Dang, Chi V.
影响因子：
4.3
作者：
Bonuccelli, Gloria;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.
影响因子：
8
作者：
Bauer, DE;Hatzivassiliou, G;Thompson, CB
通讯作者：
Thompson, CB
影响因子：
3.5
作者：
Bhat, Krishna P.;Pelloski, Christopher E.;Aldape, Kenneth D.
通讯作者：
Aldape, Kenneth D.
影响因子：
64.8
作者：
BURGERING, BMT;COFFER, PJ
通讯作者：
COFFER, PJ