Electrolytic lesions to nucleus accumbens core and shell have dissociable effects on conditioning to discrete and contextual cues in aversive and appetitive procedures respectively
Electrolytic lesions to nucleus accumbens core and shell have dissociable effects on conditioning to discrete and contextual cues in aversive and appetitive procedures respectively
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DOI：
10.1016/j.bbr.2004.12.012
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发表时间：
2005-05-28
影响因子：
2.7
通讯作者：
Norman, C
中科院分区：
文献类型：
--
作者：
Cassaday, HJ;Horsley, RR;Norman, C
伏隔核（n.acc.）与离散和情境线索的调节有关，但其确切作用尚存在争议，因为已报道了相互冲突的作用模式。这些不一致可能与所使用的病变侵占 n 不同子域的程度有关。附件以及使用不同的任务变体。本研究比较了伏隔核（n.acc.）的外壳和核心子区域选择性损伤对厌恶性和食欲性微量调节变体的影响。在这两个实验中，听觉刺激与足部电击或食物相邻，或者以微量间隔呈现。在每种情况下，连续闪烁的光都提供了实验背景刺激。还评估了对实验室提供的线索的调节。具有电解损伤的大鼠。附件壳和核在该过程的厌恶（实验 1）和食欲（实验 2）变体中表现出不同的效果模式。在实验 1 中，核心病变在响应离散噪声刺激时减少了迹线组和连续条件组之间的差异。然而，这两个损伤对情境条件反射都没有任何可检测到的影响。在实验2中，外壳损伤明显增加了情境条件作用，在痕迹条件反射组中选择性地增加，但两个损伤对离散线索条件反射没有任何可检测到的影响，因此，而外壳和核心损伤对离散线索和情境条件反射产生了可分离的影响。得出的结论取决于所使用的程序变体。 (c) 2004 Elsevier B.V 保留所有权利。
The nucleus accumbens (n. acc.) has been implicated in conditioning to both discrete and contextual cues but its precise role is as yet controversial because conflicting patterns of effect have been reported. These inconsistencies may relate to the extent to which the lesions used encroach on different subfields of n. acc. and the use of different task variants. The present study compared the effects of selective lesions of shell and core subfields of nucleus accumbens (n. acc.) across aversive and appetitive trace conditioning variants.In both experiments, an auditory stimulus was contiguous with footshock or food, or presented at a trace interval. A continuous flashing light in each case provided an experimental background stimulus. Conditioning to the cues provided by the experimental chambers was also assessed. Rats with electrolytic lesions to the n. acc. shell and core showed different patterns of effect in aversive (Experiment 1) and appetitive (Experiment 2) variants of this procedure. In Experiment 1. the core lesion reduced the difference between trace and contiguously conditioned groups, in responding to the discrete noise stimulus. However, neither lesion had any detectable effect on contextual conditioning, In Experiment 2, the shell lesion clearly increased contextual conditioning, selectively in the trace conditioned group, but neither lesion had any detectable effect on discrete cue conditioning,Thus, whilst the shell and core lesions produced dissociable effects on discrete cue and contextual conditioning. the conclusions to be drawn depend on the procedural variant in use. (c) 2004 Elsevier B.V All rights reserved.