Clonal analysis of stem cells in differentiation and disease
Clonal analysis of stem cells in differentiation and disease
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DOI：
10.1016/j.ceb.2016.07.002
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发表时间：
2016-12-01
影响因子：
7.5
通讯作者：
Jones, Philip H.
中科院分区：
文献类型：
--
作者：
Colom, Bartomeu;Jones, Philip H.
通过克隆分析跟踪单个细胞及其后代的命运重新定义了干细胞的概念及其在健康和疾病中的作用。成体组织中细胞更新的维持是通过具有相同自我更新或分化可能性的干细胞群体的集体作用来实现的。损伤后，干细胞表现出惊人的可塑性，从稳态行为转换，以修复受损组织。疾病状态对干细胞的影响也正在被揭示，对体细胞突变如何在早期肿瘤形成中引发克隆扩增有了新的见解。
Tracking the fate of individual cells and their progeny by clonal analysis has redefined the concept of stem cells and their role in health and disease. The maintenance of cell turnover in adult tissues is achieved by the collective action of populations of stem cells with an equal likelihood of self-renewal or differentiation. Following injury stem cells exhibit striking plasticity, switching from homeostatic behavior in order to repair damaged tissues. The effects of disease states on stem cells are also being uncovered, with new insights into how somatic mutations trigger clonal expansion in early neoplasia.