Inhibitors of Pyruvate Carboxylase.
Inhibitors of Pyruvate Carboxylase.
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DOI：
10.2174/1874940201003010008
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Attwood PV
中科院分区：
文献类型：
--
作者：
Zeczycki TN;Maurice MS;Attwood PV
本文综述了生物素依赖性羧化酶的抑制剂，重点介绍了丙酮酸羧化酶的抑制剂。这些抑制剂中的一些是生理学相关的，因为它们提供调节酶的细胞活性的方式，例如天冬氨酸和丙酮酸羧化酶的抑制剂。大多数的抑制剂，将讨论已被用来探测这些酶的结构和功能的各个方面。它们靶向结构的特定部分，例如抗生物素蛋白-生物素、FTP - ATP结合位点、草氨酸-丙酮酸结合位点、推定的羧基磷酸中间体的膦酰乙酸结合位点。
This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase. Some of these inhibitors are physiologically relevant, in that they provide ways of regulating the cellular activities of the enzymes e.g. aspartate and prohibitin inhibition of pyruvate carboxylase. Most of the inhibitors that will be discussed have been used to probe various aspects of the structure and function of these enzymes. They target particular parts of the structure e.g. avidin – biotin, FTP – ATP binding site, oxamate – pyruvate binding site, phosphonoacetate – binding site of the putative carboxyphosphate intermediate.