Bleb Nucleation through Membrane Peeling
Bleb Nucleation through Membrane Peeling
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DOI：
10.1103/physrevlett.116.068101
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发表时间：
2016-02-10
影响因子：
8.6
通讯作者：
Casademunt, Jaume
中科院分区：
文献类型：
--
作者：
Alert, Ricard;Casademunt, Jaume
我们研究了水泡的成核，即，由于细胞膜与皮层的局部分离而产生的突起。基于一个简单的模型与力依赖动力学的弹性链接，我们表明，水泡成核是由膜剥离。通过这种机制，脱离的膜贴片的生长或收缩完全由连接体动力学决定，而不管脱离的能量成本。我们预测了薄膜剥离的临界成核半径和相应的有效能垒。这些可能通常小于经典成核理论预测的那些，这意味着更快的成核。我们还进行了模拟的连续随机模型的膜皮质粘附，以获得统计的水泡成核时间作为膜上的应力的函数。膜剥离的决定性作用改变了我们对滤过泡成核的理解，并开辟了滤过泡研究的新方向。
We study the nucleation of blebs, i.e., protrusions arising from a local detachment of the membrane from the cortex of a cell. Based on a simple model of elastic linkers with force-dependent kinetics, we show that bleb nucleation is governed by membrane peeling. By this mechanism, the growth or shrinkage of a detached membrane patch is completely determined by the linker kinetics, regardless of the energetic cost of the detachment. We predict the critical nucleation radius for membrane peeling and the corresponding effective energy barrier. These may be typically smaller than those predicted by classical nucleation theory, implying a much faster nucleation. We also perform simulations of a continuum stochastic model of membrane-cortex adhesion to obtain the statistics of bleb nucleation times as a function of the stress on the membrane. The determinant role of membrane peeling changes our understanding of bleb nucleation and opens new directions in the study of blebs.