Missed opportunities in crystallography.
Missed opportunities in crystallography.
复制标题
错过了晶体学的机会。
DOI：
10.1111/febs.12832
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Jaskolski,Mariusz
中科院分区：
文献类型：
--
作者：
Dauter,Zbigniew;Jaskolski,Mariusz
从时间的角度来看，晶体学史上的巨人们不止一次错过了一个几乎显而易见的机会，做出另一个伟大的发现，或者走错了方向。这篇评论分析了这种错过的机会，重点是大分子晶体学家（使用佩鲁茨，鲍林，富兰克林为例），虽然特定的历史（开普勒），方法（劳厄，帕特森）或结构（鲍林，拉玛钱德朗）的相关性的情况下也进行了描述。特别是莱纳斯·鲍林，在不同的情况下多次出现，作为一个有远见的人，疏忽，甚至失明。他的例子强调了一个简单的事实，即在科学中，不断的创造力也不可避免地与某些错误的可能性有关。
Scrutinized from the perspective of time, the giants in the history of crystallography more than once missed a nearly obvious chance to make another great discovery, or went in the wrong direction. This review analyzes such missed opportunities focusing on macromolecular crystallographers (using Perutz, Pauling, Franklin as examples), although cases of particular historical (Kepler), methodological (Laue, Patterson) or structural (Pauling, Ramachandran) relevance are also described. Linus Pauling, in particular, is presented several times in different circumstances, as a man of vision, oversight, or even blindness. His example underscores the simple truth that also in science incessant creativity is inevitably connected with some probability of fault.