Effects of intragastric infusions of fat and carbohydrate on appetite ratings and food intake from a test meal
Effects of intragastric infusions of fat and carbohydrate on appetite ratings and food intake from a test meal
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DOI：
10.1006/appe.1997.0109
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发表时间：
1998-02-01
期刊：
影响因子：
5.4
通讯作者：
Read, W
中科院分区：
文献类型：
--
作者：
Cecil, JE;Castiglione, K;Read, W
之前的研究表明，碳水化合物比脂肪有更强的饱腹力。为了研究大量营养素对摄入量和饱腹感的影响，在不受膳食设计和味觉因素影响的情况下，两组10名健康、禁食的男性志愿者参加了两个单独的实验，涉及快速直接胃内注入大量营养素。在第一个实验中，志愿者在三个不同的场合接受了超过15分钟的Intralipid、1：1 Intralipid和葡萄糖混合物或生理盐水的等量热量输注。在第二个实验中，志愿者接受了Intralipid或葡萄糖的等热量输注。在这两项研究中，在研究的前两个小时记录了食欲评分，并从输液后1.5小时的试验餐中评估了能量和大量营养素的摄入量。食物日记被用来监测研究当天剩余时间的食物摄入量。在第一个实验中，与生理盐水相比，Intralipid和Intralipid/葡萄糖混合物都抑制了食欲评分，并减少了午餐时的能量摄入，但在研究当天的剩余时间里对能量摄入没有影响。在抑制食欲评级或能量摄入方面，营养条件之间没有发现差异。在第二个实验中，Intralipid和葡萄糖对饥饿、饱腹感的影响，或者对测试餐的能量摄入量或一天剩余时间摄入量的影响没有差异。综上所述，这些结果表明，胃内注入Intralipid、葡萄糖或两者的混合物可以减少饥饿感和增加饱腹感，但它们未能证实不同的常量营养素具有不同的饱腹力的假设。(C)1998年学术出版社有限公司。
Previous studies using meal preloads have indicated that carbohydrate has a greater satiating power than fat. To investigate the effects of macronutrients on ingestion and satiety, without the influence of meal design and orosensory factors, two groups of ten healthy, fasted male volunteers took part in two separate experiments involving rapid direct intragastric infusions of macronutrients. In the first experiment volunteers received isocaloric infusions of either Intralipid, or 1:1 Intralipid and glucose mixture or saline over 15 min on three separate occasions. In a second experiment volunteers received isocaloric infusions of either Intralipid or glucose. For both studies, appetite ratings were recorded for the first two hours of the study and energy and macronutrient intakes were evaluated from a test meal given 1.5 h after the infusion. Food diaries were used to monitor food intake for the remainder of the study day. In the first experiment, both Intralipid and the Intralipid/glucose mixture suppressed appetite ratings and reduced energy intake at lunch compared with saline but had no effect on energy intake during the remainder of the study day. No differences were found between nutrient conditions in suppressing appetite ratings or energy intake. In the second experiment there were no differences between the effects of Intralipid and glucose on hunger, fullness or on energy intake from the test meal or intake over the remainder of the day. Taken together, these results suggest that intragastric infusions of either Intralipid, glucose or a mixture of the two, reduced hunger and increased fullness, but they failed to confirm the hypothesis that different macronutrients have different satiating capacities. (C) 1998 Academic Press Limited.