Resting-state functional connectivity in neuropsychiatric disorders
Resting-state functional connectivity in neuropsychiatric disorders
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DOI：
10.1097/wco.0b013e328306f2c5
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发表时间：
2008-08-01
影响因子：
4.8
通讯作者：
Greicius, Michael
中科院分区：
文献类型：
--
作者：
Greicius, Michael
综述目的本综述考虑了静息态功能磁共振成像在神经精神疾病研究中应用的最新进展。最新发现静息态功能磁共振成像是一种相对较新的技术，在临床适用性方面比任务激活功能磁共振成像具有几个潜在优势。许多研究小组已经开始研究静息态功能磁共振成像在各种神经精神疾病中的应用，包括阿尔茨海默病、抑郁症和精神分裂症。尽管初步结果在某些疾病（例如阿尔茨海默氏病）中相当一致，但在其他疾病（精神分裂症）中则重现性较差。静息状态连通性已被证明与行为表现和情绪测量相关。它作为疾病的生物标志物和治疗反应的早期客观标志物的潜力是真实的，但仍有待实现。总结静息态功能磁共振成像在临床领域取得了一些进展，但在它能够在单个患者水平上以有意义的方式使用之前，还需要取得重大进展。
Purpose of reviewThis review considers recent advances in the application of resting-state functional magnetic resonance imaging to the study of neuropsychiatric disorders.Recent findingsResting-state functional magnetic resonance imaging is a relatively novel technique that has several potential advantages over task-activation functional magnetic resonance imaging in terms of its clinical applicability. A number of research groups have begun to investigate the use of resting-state functional magnetic resonance imaging in a variety of neuropsychiatric disorders including Alzheimer's disease, depression, and schizophrenia. Although preliminary results have been fairly consistent in some disorders (for example, Alzheimer's disease) they have been less reproducible in others (schizophrenia). Resting-state connectivity has been shown to correlate with behavioral performance and emotional measures. It's potential as a biomarker of disease and an early objective marker of treatment response is genuine but still to be realized.SummaryResting-state functional magnetic resonance imaging has made some strides in the clinical realm but significant advances are required before it can be used in a meaningful way at the single-patient level.