DNA COMPUTERS FOR WORK AND PLAY
DNA COMPUTERS FOR WORK AND PLAY
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DOI：
10.1038/scientificamerican1108-84
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发表时间：
2008-11-01
影响因子：
3
通讯作者：
Stojanovic, Milan N.
中科院分区：
文献类型：
--
作者：
Macdonald, Joanne;Stelanovic, Darko;Stojanovic, Milan N.
从现代化学家的角度来看，我们基因中的 DNA 结构相当平凡。该分子对生命具有众所周知的重要性，但化学家经常只看到均匀的双螺旋，其本身几乎没有功能行为。那么，当得知这种分子是连接合成化学、酶学、结构纳米技术和计算机科学的真正丰富而奇怪的研究领域的基础时，您可能会感到惊讶。利用这一新科学，我们构建了可以在水溶液中运行的分子版本的逻辑门。我们构建这些基于 DNA 的计算模块的目标是开发可以存在于生物体中的纳米机器，感知条件并根据感知做出决策，然后做出响应，例如释放药物或杀死特定细胞。
From a modern chemist's perspective, the structure of DNA in our genes is rather mundane. The molecule has a well-known importance for life, but chemists often see only a uniform double helix with almost no functional behavior on its own. It may come as a surprise, then, to learn that this molecule is the basis of a truly rich and strange research area that bridges synthetic chemistry, enzymology, structural nanotechnology and computer science. Using this new science, we have constructed molecular versions of logic gates that can operate in water solution. Our goal in building these DNA-based computing modules is to develop nanoscopic machines that could exist in living organisms, sensing conditions and making decisions based on what they sense, then responding with actions such as releasing medicine or killing specific cells.