Innate cell communication kick-starts pathogen-specific immunity.
Innate cell communication kick-starts pathogen-specific immunity.
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DOI：
10.1038/ni.3375
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发表时间：
2016-04
影响因子：
30.5
通讯作者：
Gause WC
中科院分区：
文献类型：
--
作者：
Rivera A;Siracusa MC;Yap GS;Gause WC
天然细胞负责快速识别感染和介导病原体清除的基本机制，并促进获得性免疫反应。我们在这里回顾了启动保护性免疫的天然细胞之间的许多复杂的相互作用。病原体的有效清除有赖于多种细胞的协同作用，包括天然细胞和上皮细胞。与其作为孤立的效应细胞发挥作用，天然细胞与免疫系统的其他反应细胞保持着持续的通信，无论是在局部还是在远端。这些相互作用对有效控制原发感染至关重要，也对培养“训练有素的”先天细胞以促进同源或异源感染的快速消除至关重要。
Innate cells are responsible for the rapid recognition of infection and mediate essential mechanisms of pathogen elimination, and also facilitate adaptive immune responses. We review here the numerous intricate interactions among innate cells that initiate protective immunity. The efficient eradication of pathogens depends on the coordinated actions of multiple cells, including innate cells and epithelial cells. Rather than acting as isolated effector cells, innate cells are in constant communication with other responding cells of the immune system, locally and distally. These interactions are critically important for the efficient control of primary infections as well for the development of ‘trained’ innate cells that facilitate the rapid elimination of homologous or heterologous infections.