Class IIa HDACs - new insights into their functions in physiology and pathology
Class IIa HDACs - new insights into their functions in physiology and pathology
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DOI：
10.1111/febs.13061
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发表时间：
2015-05-01
期刊：
影响因子：
5.4
通讯作者：
Parra, Maribel
中科院分区：
文献类型：
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作者：
Parra, Maribel
HDAC 4、5、7和9构成蛋白质脱乙酰酶大家族中的IIa类组蛋白脱乙酰酶（HDAC）。Class IIa HDAC具有区别于其他HDAC的独特功能。它们含有N-末端结构域，该结构域是它们与组织特异性转录因子相互作用和募集到其靶基因所必需的。IIa类HDACs的N-末端结构域还具有保守的丝氨酸残基，这些丝氨酸残基经历信号依赖性磷酸化，这导致酶的核输出和其靶标的去抑制。IIa类HDAC的最重要方面之一是它们在生物体内的特定组织和器官中的表达，在那里它们在发育和分化过程中起关键作用。这篇综述带来了最新的生理和病理功能的classIIa HDACs，特别是集中在最近的发现，从小鼠模型系统的体内研究我们的知识。
HDAC4, 5, 7 and 9 constitute the classIIa histone deacetylases (HDACs) within the large family of protein deacetylases. ClassIIa HDACs have unique features that distinguish them from other HDACs. They contain an N-terminal domain that is required for their interaction with tissue-specific transcription factors and recruitment to their target genes. The N-terminal domain on classIIa HDACs also bears conserved serine residues that undergo signal-dependent phosphorylation, which brings about nuclear export of the enzymes and de-repression of their targets. One of the most important aspects of classIIa HDACs is their expression in specific tissues and organs within the organism, where they have crucial roles in development and differentiation processes. This review brings up to date our knowledge of the physiological and pathological functions of classIIa HDACs, focusing in particular on the most recent discoveries from invivo studies of mouse model systems.