A 12-month comparison of ACE inhibitor and CA antagonist therapy in mild to moderate essential hypertension--The GLANT Study. Study Group on Long-term Antihypertensive Therapy.
A 12-month comparison of ACE inhibitor and CA antagonist therapy in mild to moderate essential hypertension--The GLANT Study. Study Group on Long-term Antihypertensive Therapy.
复制标题
ACE 抑制剂和 CA 拮抗剂治疗轻至中度原发性高血压的 12 个月比较 - GLANT 研究。
DOI：
10.1291/hypres.18.235
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
H. Matsuoka
中科院分区：
文献类型：
--
作者：
H. Matsuoka
对980例原发性轻中度高血压患者采用ACE抑制剂（地普利）或956例钙拮抗剂为主治疗12个月，比较两组心脑血管事件发生率及药物相关副作用。两组患者的临床背景差异无统计学意义。在两组中，血压从治疗1个月开始显著降低，在整个研究期间，Ca拮抗剂组的降低程度更大（p <0.001）。地普利组980例患者中有11例发生脑血管或心血管事件，钙拮抗剂组956例患者中有18例发生脑血管或心血管事件（p = NS）。5例接受地拉普利治疗的患者和11例接受钙拮抗剂治疗的患者发生了脑血管疾病，分别有5例和7例患者发生了心脏病（均为p = NS）。地普利组因副作用而停止治疗的情况明显多于钙拮抗剂组（p <0.001）。两组脑血管和心血管事件的发生率无显著差异，结果表明血压降低本身并不一定导致脑血管和心血管并发症的平行减少。
Patients with mild to moderate essential hypertension were treated mainly with an ACE inhibitor (delapril, n = 980) or a Ca antagonist (n = 956) for 12 months, and the incidence of cerebrovascular and cardiovascular events as well as drug-related side effects were compared between the two groups. There were no significant differences between the clinical backgrounds of the two groups. In both groups, the blood pressure was decreased significantly from 1 month of treatment onwards, with the degree of reduction being greater in the Ca antagonist group throughout the study period (p < 0.001). Cerebrovascular or cardiovascular events occurred in 11 out of 980 patients in the delapril group and 18 out of 956 patients in the Ca antagonist group (p = NS). Cerebrovascular disease developed in 5 delapril-treated patients and 11 Ca antagonist-treated patients, and heart disease developed in 5 and 7 patients, respectively (both p = NS). Discontinuation of treatment due to side effects was significantly more common in the delapril group than in the Ca antagonist group (p < 0.001). There was no significant difference in the incidence of cerebrovascular and cardiovascular events between the two groups, and the results suggested that blood pressure reduction per se did not necessarily lead to a parallel decrease in cerebrovascular and cardiovascular complications.
影响因子：
120.7
作者：
NEATON, JD;GRIMM, RH;LIEBSON, PR
通讯作者：
LIEBSON, PR