The inactivation of Chinese hamster cells by x rays: the effects of chemical modifiers on single- and double-events.
The inactivation of Chinese hamster cells by x rays: the effects of chemical modifiers on single- and double-events.
复制标题
X 射线对中国仓鼠细胞的灭活：化学修饰剂对单事件和双事件的影响。
作者：
J. Chapman;C. J. Gillespie;A. P. Reuvers;D. L. Dugle
中国仓鼠成纤维细胞增殖能力的辐射灭活通过线性-二次关系来描述，S/S$sub 0$ = exp (-$alpha$D - $beta$D$sup 2$)。已确定在各种化学辐射防护和放射增敏条件下照射的异步细胞的 $alpha$ 和 $beta$ 值。已发现 OH 通过 $alpha$（单事件）和 $beta$（双事件）导致细胞失活。发现巯基修复可提供针对单事件和双事件的放射防护，而分子氧主要通过增强双事件来提供放射增敏作用。电子亲和放射增敏剂增强了双事件成分。参考潜在的分子靶标和病变以及水中 250 kV X 射线的微剂量测定，讨论了这些辐射化学效应对细胞失活的影响。 （授权）
The radiation inactivation of the proliferative capacity of Chinese hamster fibroblasts is described by the linear--quadratic relationship, S/S$sub 0$ = exp (-$alpha$D - $beta$D$sup 2$). Values of $alpha$ and $beta$ have been determined for asynchronous cells irradiated under various conditions of chemical radioprotection and radiosensitization. OH has been found to contribute to cell inactivation by both $alpha$ (single-events) and $beta$ (double-events). Sulfhydryl repair was found to provide radioprotection against single- and double- events while molecular oxygen was found to radiosensitize predominantly by enhancing double-events. Electron-affinic radiosensitizers enhanced the double- event component. These radiation chemical effects on cell inactivation are discussed with reference to potential molecular targets and lesions and the microdosimetry of 250 kV X rays in water. (auth)