Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression:: no alteration of soluble gp130
Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression:: no alteration of soluble gp130
复制标题
DOI：
10.1016/s0304-3940(98)00916-1
复制
发表时间：
1999-01-15
影响因子：
2.5
通讯作者：
Hampel, H
中科院分区：
文献类型：
--
作者：
Stübner, S;Schön, T;Hampel, H
白细胞介素-6 （IL-6）被认为在免疫机制和中枢神经系统的相互作用中起重要作用。我们研究了老年抑郁症（MD）患者脑脊液（CSF）中白细胞介素-6 （IL-6）、可溶性IL-6受体（sIL-6R）和可溶性信号转导和亲和转换受体gp130 （sgp130）的浓度是否发生改变。采用酶联免疫吸附试验（ELISA）分析了20例老年MD患者和20例年龄匹配的健康对照者脑脊液中sIL-6R复合物三组分的浓度。除1例患者外，其余患者均接受精神药物治疗。我们发现MD患者脑脊液中IL-6和sIL-6R的浓度有统计学意义的降低（P < 0.001）。sgp130的水平在患者和对照组之间无统计学意义的差异。1999爱思唯尔科学爱尔兰有限公司版权所有。
Interleukin-6 (IL-6) is hypothesized to play an important role in the interaction between immune mechanisms and the central nervous system. We investigated whether cerebrospinal fluid (CSF) concentrations of interleukin-6 (IL-6), the soluble (IL-6 receptor (sIL-6R) and the soluble form of the signal transducing and affinity converting receptor gp130 (sgp130) are altered in geriatric patients with major depression (MD). In 20 geriatric patients with MD and 20 age-matched healthy control subjects CSF concentrations of the three components of the sIL-6R complex were analyzed by enzyme-linked immunosorbent assays (ELISA). Ail patients except one were treated with psychotropic drugs. We found statistically significant decreased CSF concentrations of IL-6 (P < 0.001) and of the sIL-6R (P < 0.001) of patients with MD. Levels of sgp130 showed no statistically significant difference between patients and controls. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.