Cholinergic modulation of sensory representations in the olfactory bulb
Cholinergic modulation of sensory representations in the olfactory bulb
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DOI：
10.1016/s0893-6080(02)00061-8
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发表时间：
2002-06-01
期刊：
影响因子：
7.8
通讯作者：
Cleland, TA
中科院分区：
文献类型：
--
作者：
Linster, C;Cleland, TA
我们提出了一个哺乳动物嗅球(OB)的计算模型，旨在研究胆碱能输入如何调节嗅觉表征。该模型将来自OB回路胆碱能调节的不同生理学研究的实验数据整合到模拟球对现实气味的反应中。模拟了实验观察到的对一系列同源气味(未支化的脂肪醛)的反应；OB模型的真实胆碱能输入有助于提高对非常相似的气味产生的球状反应的辨别能力。这一模拟正确地预测到，没有胆碱能输入到OB将导致相似的脂肪醛之间更大的泛化。基于两个感觉刺激的神经表征之间的重叠可以预测它们的知觉相似性的假设，我们在大鼠的行为实验中验证了这一预测。事实上，我们发现，选择性损伤胆碱能神经元投射到OB和皮质的大鼠，与接受假损伤的大鼠相比，对碳链长度相似的脂肪醛的区分能力较差。(C)2002爱思唯尔科学有限公司。保留所有权利。
We present a computational model of the mammalian olfactory bulb (OB) designed to investigate how cholinergic inputs modulate olfactory sensory representations. The model integrates experimental data derived from diverse physiological studies of cholinergic modulation of OB circuitry into a simulation of bulbar responses to realistic odorants. Experimentally-observed responses to a homologous series of odorants (unbranched aliphatic aldehydes) were simulated; realistic cholinergic inputs to the OB model served to increase the discriminability of the bulbar responses generated to very similar odorants. This simulation predicted, correctly, that missing cholinergic inputs to the OB would result in greater generalization between similar aliphatic aldehydes. Based on the assumption that the overlap between the neural representations of two sensory stimuli is predictive of their perceptual similarity, we tested this prediction in a behavioral experiments with rats. We show that, indeed, rats with selective lesions of cholinergic neurons that project to the OB and cortex discriminate less well between aliphatic aldehydes with similar carbon chain lengths than do rats that received sham lesions. (C) 2002 Elsevier Science Ltd. All rights reserved.