Frequency-domain techniques enhance optical mammography: Initial clinical results
Frequency-domain techniques enhance optical mammography: Initial clinical results
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DOI：
10.1073/pnas.94.12.6468
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发表时间：
1997-06-10
影响因子：
11.1
通讯作者：
Kaschke, M
中科院分区：
文献类型：
--
作者：
Franceschini, MA;Moesta, KT;Kaschke, M
我们提出了一种新的光学乳房X线摄影方法和初步临床结果。我们设计并开发了一种频域（110 MHz）光学扫描仪，可在大约 3 分钟内对女性乳房进行透照光栅扫描，探测光为双波长（690 和 810 nm，10 mW 平均功率）、直径 2 mm 的激光束，检测光纤直径为 5 mm。使用执行边缘效应校正的算法处理交流幅度和相位数据，从而增强图像对比度。与简单的光强度图像相比，这种对比度增强导致肿瘤可检测性更高。光学乳房 X 光照片实时显示在计算机屏幕上。我们展示了两名乳腺肿瘤患者的 X 射线和光学乳房 X 光照片。我们的初步临床结果表明，频域扫描仪即使在目前的开发阶段，也有可能成为乳房X光检查的有用工具。
We present a novel approach to optical mammography and initial clinical results. We have designed and developed a frequency-domain (110-MHz) optical scanner that performs a transillumination raster scan of the female breast in approximately 3 min, The probing light is a dual-wavelength (690 and 810 nm, 10-mW average power), 2-mm-diameter laser beam, and the detection optical fiber is 5 mm in diameter. The ac amplitude and phase data are processed with use of an algorithm that performs edge effect corrections, thereby enhancing image contrast. This contrast enhancement results in a greater tumor detectability compared with simple light intensity images, The optical mammograms are displayed on a computer screen in real time, We present x-ray and optical mammograms from two patients with breast tumors. Our initial clinical results show that the frequency-domain scanner, even at the present stage of development, has the potential to be a useful tool in mammography.