Effects of altering ventricular rate on blood flow distribution in conscious dogs.
Effects of altering ventricular rate on blood flow distribution in conscious dogs.
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改变心室率对清醒狗血流分布的影响。
DOI：
10.1152/ajplegacy.1971.221.5.1402
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
E. Braunwald
中科院分区：
文献类型：
--
作者：
S. White;T. Patrick;C. Higgins;S. Vatner;D. Franklin;E. Braunwald
怀特、萨克森、托马斯·帕特里克、查尔斯·B·希金斯、斯蒂芬·F·瓦特纳、迪恩·富兰克林和尤金·布劳恩瓦尔德。改变心室率对清醒狗血液分布的影响。是。 J.生理学。 221(5)：1402-1407。 1971.-在八只患有慢性房室传导阻滞的清醒狗身上研究了外周血管对心室率逐步变化的反应。使用长期植入的压力计和多普勒超声或电磁流量传感器测量全身动脉压、心输出量和左回旋冠状动脉、肠系膜动脉、肾动脉和髂外动脉的流量。在 110 至 180 次/分钟之间，动脉压和心输出量与心室率无关，但随着心室率进一步升高或降低而下降。全身血管阻力以最低的速度上升。在外周循环中，冠脉流量持续上升，肾流量保持不变，心率从 40 次/分钟升至 220 次/分钟，而肠系膜和后肢流量则以较低的速率下降。突然停止 100 次/分钟的起搏，随后出现 6 至 12 次心搏停止，动脉压降至 20 毫米汞柱，所有床位的血流均停止。心室收缩恢复时，自发心率平均为 52 次/分钟，血流动力学模式与最低起搏速率时的血流动力学模式相似，后肢流动阻力上升到最大程度（132 =t 4.7 y0 对照），而冠状循环则较少（119 rt 7.5 y0 对照）。肠系膜循环变化不大，肾阻力下降（81 =t 对照的5.4%）。
WHITE, SAXON, THOMAS PATRICK, CHARLES B. HIGGINS, STEPHEN F. VATNER,DEAN FRANKLIN, AND EUGENE BRAUNWALD. Effects of altering ventricular rate on blood Jlow distribution in conscious dogs. Am. J. Physiol. 221(5): 1402-1407. 1971.-The peripheral vascular response to stepwise changes in ventricular rate was studied in eight conscious dogs with chronic atrioventricular block. Systemic arterial pressure, cardiac output, and flows in the left circumflex coronary, mesenteric, renal, and external iliac arteries were measured using chronically implanted pressure gauges and Doppler ultrasonic or electromagnetic flow transducers. Between 110 and 180 beats/min, arterial pressure and cardiac output were independent of ventricular rate, but fell as rate was further raised or lowered. Total systemic vascular resistance rose at the lowest rates. In the peripheral circulation, coronary flow rose continuously and renal flow remained unchanged as rate was elevated from 40 to 220 beats/min, while mesenteric and hindlimb flows fell at lower rates. Sudden cessation of pacing at 100 beats/min was followed by asystole from 6 to 12 set, a fall in arterial pressure to 20 mm Hg, and flow in all beds ceased. On resumption of ventricular contraction, to spontaneous rates averaging 52 beats/min, the hemodynamic pattern resembled that seen at the lowest pacing rates with flow resistance rising to the greatest extent in the hindlimb (132 =t 4.7 y0 of control) and less so in the coronary circulation (119 rt 7.5 y0 of control). There was little change in the mesenteric circulation, and renal resistance decreased (81 =t 5.4% of control).