Region-specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons
Region-specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons
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作者：
Hall, AC;Mira, H;Arenas, E
放射状胶质细胞（RG）是神经系统中最早出现的胶质细胞类型。它们的广泛分布和明显的相似性隐藏了重要的大脑区域特异性差异，这些差异可能对发育至关重要。然而，最近的证据支持刺激概念，即除了作为成神经细胞向导的经典功能之外，RG是神经元前体（Malatesta等，Development 127：52535263，2000; Miyata等，Neuron 31：727-741，2001; Noctor等，Nature 409：714-720，2001; Skogh等，Mol Cell Neurosci 17：811-820，2001）。我们认为，RG不仅产生和指导新生神经元，但也可以指导自己的神经元后代采取适当的区域特异性表型。(C)2003 Wiley-Liss，Inc.
Radial glia (RG) are the first glial cell type to appear in the nervous system. Their broad distribution and apparent similarity hide important brain region-specific differences that are likely to be essential for development. However, recent evidence supports the stimulating concept that in addition to their classical function as neuroblast guides, RG are neuronal precursors (Malatesta et al. Development 127:52535263, 2000; Miyata et al. Neuron 31:727-741, 2001; Noctor et al. Nature 409:714-720, 2001; Skogh et al. Mol Cell Neurosci 17:811-820, 2001). We propose that RG not only generate and guide newborn neurons, but could also instruct their own neuronal progeny to adopt appropriate region-specific phenotypes. (C) 2003 Wiley-Liss, Inc.