Sustained release of mitomycin-C from poly(DL-lactide) /poly(DL-lactide-co-glycolide) films
Sustained release of mitomycin-C from poly(DL-lactide) /poly(DL-lactide-co-glycolide) films
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DOI：
10.1163/156856200743562
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发表时间：
2000-01-01
影响因子：
3.6
通讯作者：
Deniz, G
中科院分区：
文献类型：
--
作者：
Gümüsderelioglu, M;Deniz, G
采用溶剂挥发法制备了不同载药量和不同厚度的丝裂霉素-C(MMC)载药聚(DL-丙交酯)/聚乙交酯(PLGA)薄膜。在37℃、pH 7.4的磷酸盐缓冲盐水中进行降解和释放研究。结果表明，当共聚物中乙交酯含量从10%增加到30%(w/w)，载药量从0.5 mg/300 mg增加到2 mg/300 mg时，MMC的释放率和释药率都增加，而随着薄膜厚度和聚合物相对分子质量的增加，MMC的释放率和释药率都有所下降。结果表明，药物的释放机制为扩散控制，符合非Fickian扩散机制。
Mitomycin-C (MMC)-loaded poly(DL-lactide) (PLA)/ poly(DL-lactide-co-glycolide) (PLGA) films which have different drug loading capacities and thicknesses were prepared by a solvent-evaporation technique. Degradation and release studies were conducted at 37 degreesC in pH 7.4 phosphate buffered saline. The results showed that both the rate and the percentage of released MMC increased as the glycolide content in the copolymer increased from 10 to 30% (w/w) and the drug load increased from 0.5 to 2 mg MMC per 300 mg of polymer In contrast, they decreased depending upon increasing film thickness from 80 to 300 mum and polymer molecular weight. It was found that the drug release mechanism is diffusion-controlled according to a non-Fickian diffusion mechanism.