How to design magneto-based total analysis systems for biomedical applications.
How to design magneto-based total analysis systems for biomedical applications.
复制标题
DOI：
10.1016/j.bios.2010.06.031
复制
发表时间：
2010-12
影响因子：
12.6
通讯作者：
A. Weddemann;C. Albon;A. Auge;F. Wittbracht;P. Hedwig;D. Akemeier;Karsten Rott;D. Meißner;Peter Jutzi;Andreas Hütten
中科院分区：
文献类型：
--
作者：
A. Weddemann;C. Albon;A. Auge;F. Wittbracht;P. Hedwig;D. Akemeier;Karsten Rott;D. Meißner;Peter Jutzi;Andreas Hütten
本文综述了纳米尺度传感器用于磁珠或纳米颗粒磁阻检测的最新进展。传感器分析从实验和数值的角度来看，他们的能力，无论是本地化的位置，一个单一的磁性粒子或检测粒子的数量在一定范围内。指南显示了如何扩展单个传感器的传感器阵列具有非常高的空间分辨率，以及如何修改传感器的形状，以提供长距离的测量。此外，生物芯片实验室环境中的传感器进行了讨论。磁棘轮和重力为基础的微流体组件进行审查的重要工具，以定位，因此，检测连续流动装置中的生物成分。
This article reviews recent developments on magnetoresistive detection of magnetic beads or nanoparticles by nanoscale sized sensors. Sensors are analyzed from an experimental and a numerical point of view in respect to their capability to either localize the position of a single magnetic particle or to detect the number of particles in a certain range. Guidelines are shown up on how to extend single sensors to sensor arrays with very high spatial resolution and how to modify the sensor shape in order to provide long distance measurements. Further, sensors in biological lab-on-a-chip environments are discussed. The magnetic ratchet and a gravitation based microfluidic component are reviewed as important tools to position and, therefore, detect biological components in continuous-flow devices.