Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study
Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study
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DOI：
10.3233/jad-2009-0920
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发表时间：
2009-01-01
影响因子：
4
通讯作者：
Kivipelto, Miia
中科院分区：
文献类型：
--
作者：
Eskelinen, Marjo H.;Ngandu, Tiia;Kivipelto, Miia
咖啡因在短期内刺激中枢神经系统。然而，咖啡因对认知的长期影响仍不清楚。我们的目的是研究中年时喝咖啡和/或茶与晚年痴呆/阿尔茨海默病（AD）风险之间的关系。心血管危险因素、衰老和痴呆（CAIDE）研究的参与者是从1972年、1977年、1982年或1987年（中年访视）在北卡累利阿项目和FINMONICA研究中进行过调查的基于人群的队列的幸存者中随机选择的。经过平均21年的随访，1998年有1409名65至79岁的人（71%）完成了重新检查。共有61例被确定为痴呆症（48例AD）。与不喝或只喝少量咖啡的人相比，中年时喝咖啡的人在晚年患痴呆症和AD的风险较低，这些风险经过人口统计学、生活方式和血管因素、载脂蛋白E β 4等位基因和抑郁症状的调整。每天喝3-5杯的人风险最低（降低65%）。饮茶相对不常见，与痴呆/AD无关。中年时喝咖啡与晚年痴呆/AD的风险降低有关。这一发现可能为预防痴呆/AD提供了可能性。
Caffeine stimulates central nervous system on a short term. However, the long-term impact of caffeine on cognition remains unclear. We aimed to study the association between coffee and/or tea consumption at midlife and dementia/Alzheimer's disease (AD) risk in late-life. Participants of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study were randomly selected from the survivors of a population-based cohorts previously surveyed within the North Karelia Project and the FINMONICA study in 1972, 1977, 1982 or 1987 (midlife visit). After an average follow-up of 21 years, 1409 individuals (71%) aged 65 to 79 completed the re-examination in 1998. A total of 61 cases were identified as demented (48 with AD). Coffee drinkers at midlife had lower risk of dementia and AD later in life compared with those drinking no or only little coffee adjusted for demographic, lifestyle and vascular factors, apolipoprotein E epsilon 4 allele and depressive symptoms. The lowest risk (65% decreased) was found in people who drank 3-5 cups per day. Tea drinking was relatively uncommon and was not associated with dementia/AD. Coffee drinking at midlife is associated with a decreased risk of dementia/AD later in life. This finding might open possibilities for prevention of dementia/AD.