The impact of receiving genetic test results on general and cancer-specific psychologic distress among members of an African-American kindred with a BRCA1 mutation.
The impact of receiving genetic test results on general and cancer-specific psychologic distress among members of an African-American kindred with a BRCA1 mutation.
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接受基因检测结果对具有 BRCA1 突变的非裔美国人亲属的一般和癌症特异性心理困扰的影响。
DOI：
10.1002/cncr.21479
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Smith,Ken
中科院分区：
文献类型：
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作者：
Kinney,AnitaYeomans;Bloor,LindseyE;Mandal,Diptasri;Simonsen,SaraEllis;Baty,BonnieJeanne;Holubkov,Richard;Seggar,Kate;Neuhausen,Susan;Smith,Ken
BACKGROUNDNumerous studies have examined short‐term and long‐term psychologic responses to genetic testing for breast/ovarian carcinoma susceptibility in clinic samples and among families who participated in genetic linkage studies. However, to the authors' knowledge, the vast majority of studies focused on non‐Latino whites and women. In this prospective study, the authors investigated the psychologic impact of receiving carrier‐specificBRCA1test results as part of a genetic education/counseling intervention in female and male members of an African‐American kindred with aBRCA1mutation.METHODSEighty‐five of 101 participating kindred members (84%) underwent genetic counseling/education and testing according to an established protocol. Participants completed in‐person or telephone‐administered, computer‐assisted interviews. At baseline and after the receipt of test results (1 mo, 4 mos, and 12 mos), general psychologic distress (i.e., anxiety and depression) and cancer‐specific distress were measured. Statistical analyses were performed using linear mixed‐model approaches for longitudinal data.RESULTSThe hypothesis that mutation carriers, particularly women who had no personal history of breast carcinoma, were expected to report greater distress than noncarriers was not supported. After controlling for socioeconomic status and personal history of breast/ovarian carcinoma, noncarriers reported significant declines in the distress measures (depressive symptoms, anxiety and cancer‐related worries), whereas distress was not altered markedly in carriers after genetic risk notification.CONCLUSIONSThe current findings suggested that individuals receivingBRCA1test results who learn that they are not carriers of a deleterious mutation may experience psychologic benefits. Furthermore, those who learned that they were mutation carriers did not appear to have adverse, clinically meaningful psychologic outcomes. Cancer 2005. © 2005 American Cancer Society.
