Incidence and epidemiology of non-Hodgkin lymphoma and risk of second malignancy among 22466 survivors in Israel with 30 years of follow-up
Incidence and epidemiology of non-Hodgkin lymphoma and risk of second malignancy among 22466 survivors in Israel with 30 years of follow-up
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DOI：
10.1002/hon.2302
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发表时间：
2017-12-01
影响因子：
3.3
通讯作者：
Polliack, Aaron
中科院分区：
文献类型：
--
作者：
Tadmor, Tamar;Liphshitz, Irena;Polliack, Aaron
以往的研究表明，非霍奇金淋巴瘤(NHL)后继发恶性肿瘤的风险增加，这可能与遗传易感性、分子背景、宿主免疫学状态和治疗方法等综合因素有关。在这里，我们确定了1980-2011年间以色列确诊的NHL幸存者中NHL的发病率以及继发实体瘤和血液恶性肿瘤的风险。数据是从以色列国家癌症登记处的记录中收集的。24666名非霍奇金淋巴瘤患者包括22601名犹太人和2065名阿拉伯人。犹太人确诊的中位年龄为61.3岁，阿拉伯患者为48.2岁。在患有非霍奇金淋巴瘤的犹太人中，11265人(50%)是欧洲裔美国人，5005人(22%)是亚洲人或非洲人，6114人(27%)出生在以色列。2010年NHL幸存者、1918名犹太人和92名阿拉伯人发生了第二癌，分别占8.5%和4.5%。所有记录地点的第二种恶性肿瘤比一般人群更常见，标准化发病率(SIR)犹太男子为1.28，犹太妇女为1.25，阿拉伯男子为1.73，阿拉伯妇女为1.98。这种较高的风险在309例继发性血液系统恶性肿瘤(继发性血液系统恶性肿瘤分别为1.97、1.81、4.48和4.15)中更为明显。我们的发现表明，在以色列诊断出非霍奇金淋巴瘤后，发生第二种恶性肿瘤的风险增加，特别是白血病和非霍奇金淋巴瘤等血液系统恶性肿瘤。我们报告的非霍奇金淋巴瘤的发病率和发生在犹太人和阿拉伯人中的第二种恶性肿瘤类型的差异表明，种族和遗传易感性可能是重要的相关危险因素。版权所有(C)2016 John Wiley&Sons，Ltd.
Previous studies have shown an increase risk of second malignancies after non-Hodgkin's lymphoma (NHL), which is probably related to a combination of factors including genetic predisposition, molecular background, host immunological status and therapy administered. Here, we determined the incidence of NHL and risk of second solid tumours and haematological malignancies among survivors of NHL diagnosed in Israel during 1980-2011. Data were collected from the records of the Israeli National Cancer Registry. The total cohort of 24 666 NHL-patients included 22 601 Jews and 2065 Arabs. Median age of diagnosis for Jews was 61.3 years and 48.2 for Arab patients. Of the Jews with NHL, 11 265 (50%) were of European-American origin, 5005 (22%) Asian or African and 6114 (27%) were born in Israel. Second cancers were recorded in 2010 NHL survivors, 1918 Jews and 92 Arabs, representing a rate of 8.5%, and 4.5% o, respectively. Second malignancies in all recorded sites were more frequent than in the general population, with a standardized incidence ratio (SIR) of 1.28 for Jewish men, 1.25 for Jewish women, 1.73 for Arab men and 1.98 for Arab women. This higher risk was even more pronounced for the 309 cases with secondary haematological malignancies (secondary haematological malignancies of 1.97, 1.81, 4.48 and 4.15, respectively). Our findings show that there is an increased risk of second malignancies occurring after diagnosis of NHL in Israel, particularly for haematological malignancies such as leukaemia and NHL. The differences we report in the incidence of NHL and the types of second malignancies occurring among Jews and Arabs suggest that ethnicity and genetic susceptibility may be important relevant risk factors. Copyright (C) 2016 John Wiley & Sons, Ltd.