Sentinel node staging of resectable colon cancer: results of a multicenter study.
Sentinel node staging of resectable colon cancer: results of a multicenter study.
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可切除结肠癌的前哨淋巴结分期：多中心研究的结果。
DOI：
10.1097/01.sla.0000140753.41357.20
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发表时间：
2004
影响因子：
9
通讯作者：
Compton,Carolyn
中科院分区：
文献类型：
--
作者：
Bertagnolli,Monica;Miedema,Brent;Redston,Mark;Dowell,Jeannette;Niedzwiecki,Donna;Fleshman,James;Bem,Jiri;Mayer,Robert;Zinner,Michael;Compton,Carolyn
方法：在肿瘤周围注射1%异硫氰蓝，然后在10分钟内识别所有LN。91名患者中的79名接受SN取样，然后进行结节的多节段切割术(MLS)，由单一研究病理学家进行检查。结果：根据标准组织病理学，7名患者的原发疾病要么是良性的，要么不是结肠癌，因此被排除在进一步的研究之外。在所研究的72例结肠癌中，48例(66%)为淋巴结阴性，24例(33%)有淋巴结转移。66例(92%)定位成功，平均每例有2.1个结节。24例结节阳性患者中14例SNS阴性(58%)。MLS检出1例SN中的肿瘤，使SN检查的假阴性率达到54%。结论：这项多机构研究发现，对于结节阳性的结肠癌患者，MLS的SN检查未能预测54%的结节状态。我们的结论是，单独使用SN和MLS抽样不太可能改善可切除结肠癌的风险分层。
Methods:SN sampling involved peritumor injection of 1% isosulfan blue, followed by identification of all LN visualized within 10 minutes. SN sampling was performed on 79 of 91 patients enrolled, followed by multilevel sectioning (MLS) of the nodes and examination by a single study pathologist.Results:By standard histopathology, 7 patients had primary disease that was either benign or not colon cancer and were therefore excluded from further studies. Of 72 colon cancer cases studied, 48 (66%) were node-negative and 24 (33%) contained nodal metastases. SNs were successfully located in 66 cases (92%), with an average of 2.1 nodes per patient. SNs were negative in 14 of 24 node-positive cases (58%). MLS revealed tumor in a SN in 1 of these cases, bringing the false-negative rate of SN examination to 54%.Conclusion:This multi-institutional study found that for patients with node-positive colon cancer, SN examination with MLS failed to predict nodal status in 54% of cases. We conclude that SN sampling with MLS, used alone, is unlikely to improve risk stratification for resectable colon cancer.